Acta Cryst. (2010). E66, o2511  [ doi:10.1107/S1600536810035294 ]

Trihexyphenidyl hydrochloride: a powder diffraction study

E. Maccaroni, L. Malpezzi and N. Masciocchi

Abstract: In the cation of the title compound [systematic name: 1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride], C₂₀H₃₂NO⁺·Cl^-, the cyclohexyl and piperidine rings are in chair conformations. In the crystal structure, cations and anions are linked into chains along the c-axis direction via O-HCl and N-HCl hydrogen bonds. Weak intermolecular C-HCl interactions link further these chains into layers parallel to the bc plane. The salt, obtained from a racemic solution, was found to crystallize in the chiral P2₁2₁2 space group, indicating that, in the absence of any evident chirality-inducing process, the polycrystalline powders consist of an equivalent mixture of R and S enantiomers, forming a racemic conglomerate.

Online 4 September 2010

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