5-Bromo-2-(4-chlorophenyl)-3-ethylsulfinyl-7-methyl-1-benzofuran

In the title compound, C17H14BrClO2S, the 4-chlorophenyl ring makes a dihedral angle of 13.42 (4)° with the mean plane of the benzofuran ring. In the crystal, pairs of intermolecular Br⋯O contacts [3.125 (1) Å] link the molecules into centrosymmetric dimers, which are further linked via intermolecular C—H⋯O hydrogen bonds.

In the title compound, C 17 H 14 BrClO 2 S, the 4-chlorophenyl ring makes a dihedral angle of 13.42 (4) with the mean plane of the benzofuran ring. In the crystal, pairs of intermolecular BrÁ Á ÁO contacts [3.125 (1) Å ] link the molecules into centrosymmetric dimers, which are further linked via intermolecular C-HÁ Á ÁO hydrogen bonds.
In the title molecule ( Fig. 1), the benzofuran unit is essentially planar, with a mean deviation of 0.019 (1) Å from the least-squares plane defined by the nine constituent atoms. The dihedral angle formed by the mean plane of the benzofuran ring and the 4-chlorophenyl ring is 13.42 (4)° . The molecular packing ( Fig. 2) is stabilized by a Br···O halogen-bonding between the bromine and the oxygen of the S═O unit [Br···O2 ii = 3.125 (1) Å, C4-Br···O2 ii = 167.44 (6)° .] (Politzer et al., 2007). The crystal packing (Fig. 2) is further stabilized by a weak intermolecular C-H···O hydrogen bond between the methyl H atom of the ethyl group and the S═O unit (C17-H17B···O2 i ; Table 1).

Experimental
77% 3-chloroperoxybenzoic acid (179 mg, 0.8 mmol) was added in small portions to a stirred solution of 5-bromo-2-(4chlorophenyl)-3-ethylsulfanyl-7-methyl-1-benzofuran (318 mg, 0.8 mmol) in dichloromethane (40 mL) at 273 K. After being stirred at room temperature for 3h, the mixture was washed with saturated sodium bicarbonate solution and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated at reduced pressure. The residue was purified by column chromatography (hexane-ethyl acetate, 2:1 v/v) to afford the title compound as a colorless solid [yield 79%, m.p. 443-444 K, R f = 0.63 (hexane-ethyl acetate, 2:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by slow evaporation of a solution of the title compound in tetrahydrofuran at room temperature.

Refinement
All H atoms were positioned geometrically and refined using a riding model, with C-H = 0.93 Å for aryl, 0.97 Å for methylene, and 0.96 Å for methyl H atoms. U iso (H) = 1.2U eq (C) for aryl and methylene H atoms, and 1.5U eq (C) for methyl H atoms.
supplementary materials sup-2 Figures Fig. 1. The molecular structure of the title compound with the atom numbering scheme. Displacement ellipsoids are drawn at the 50% probability level. H atoms are presented as a small spheres of arbitrary radius.

Special details
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > 2sigma(F 2 ) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.