N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methoxybenzamide

In the title compound, C16H11F3N2O2, the carboxamide group connecting the two aromatic rings is in a syn-periplanar configuration; the molecule is non-planar; the dihedral angle between the two aromatic rings is 13.95 (18)°. Intramolecular N—H⋯O and C—H⋯O hydrogen bonds occur. In the crystal, molecules are linked by intermolecular C—H⋯O hydrogen bonds.

In the title compound, C 16 H 11 F 3 N 2 O 2 , the carboxamide group connecting the two aromatic rings is in a syn-periplanar configuration; the molecule is non-planar; the dihedral angle between the two aromatic rings is 13.95 (18) . Intramolecular N-HÁ Á ÁO and C-HÁ Á ÁO hydrogen bonds occur. In the crystal, molecules are linked by intermolecular C-HÁ Á ÁO hydrogen bonds.

Related literature
For nucleosome, a repeat unit of chromatin, see: Luger & Richmond (1998). For the biological activity of substituted amide derivatives, see: Bylov et al. (1999); Gududuru et al. (2004). For the preparation of the title compound, see: Mantelingu et al. (2007). For a related structure, see: Saeed et al. (2010).  Table 1 Hydrogen-bond geometry (Å , ). Nucleosome, a repeat unit of chromatin is made up of an octameric histone core, bearing two copies of H2A, H2B, H3 and H4 with 145-147 bp DNA wrapped around the central domain (Luger & Richmond, 1998). Several chromatin modifiers are reponsible for adding different post-translational marks like acetylation, methylation, phosphorylation and others on N-terminal histone tails and for dictating the degree of genomic compaction. Histone acetyltransferases add the acetyl group on the specific lysine of histone H3 and H4 N-terminal, and these signatures increase the accessibility of the underlying chromatin at specific genes or over vast regions of the genome. Compounds comprising an amide bond as backbone have a wide range of biological activities. Among the natural and synthetic substituted amide derivatives, there are compounds possessing anti-proliferative (Gududuru et al. 2004), anti-viral, antimalarial, general anesthetics, anti-inflammatory (Bylov et al. 1999 and anti-microbial properties. In continuation of our research on benzamides, we have synthesized the title compound by the condenstation reaction and herein we report the single X-ray crystal structure of N-(4-cyano-3-(trifluoromethyl)phenyl)-2-

methoxybemzamide.
A perspective view of the title compound is shown in Fig. 1. The carboxamide group connecting the two aromatic rings is in syn-periplanar-configuration. This is indicated by the torsion angle value of -7.6 (5)° about the atoms C6-N7-C8-O17.

Special details
Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and tor-

sion angles
Refinement. Refinement on F 2 for ALL reflections except those flagged by the user for potential systematic errors. Weighted Rfactors wR and all goodnesses of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The observed criterion of F 2 > σ(F 2 ) is used only for calculating -R-factor-obs etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å 2 )
x y z U iso */U eq F19 0.08492 (17