Acta Cryst. (2011). E67, o113-o114 [ doi:10.1107/S1600536810050737 ]
Abstract: The title schulzeine derivative, C22H24N2O4, crystallizes with two crystallographically independent molecules of almost identical conformation in the asymmetric unit. The tricyclic core of schulzeine has a fused-three-ring system comprising the tetrahydroisoquinoline and -lactam moieties. In both molecules, the pyridine ring adopts a twisted-boat conformation, whereas the lactam ring is in a boat conformation. The two methoxy groups are slightly twisted from the attached benzene ring [C-O-C-C torsion angles = -21.3 (2) and -20.5 (2)° in molecule A, and -6.3 (2) and -16.2 (2)° in molecule B] and the benzamide moiety is in a (-)-synclinal conformation with respect to the lactam ring. In the crystal, molecules are linked into V-shaped dimers by intermolecular N-HO hydrogen bonds and weak C-HO interactions. These dimers are stacked into V-shaped columns along the a axis. Adjacent columns are further linked in an antiparallel manner. C-H interactions are also observed.
Online 11 December 2010
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