Received 23 February 2011
aDepartment of Respiratory Medicine, Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China,bModern Medical Research Center, Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China, and cDepartment of Pharmacy, Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China
Correspondence e-mail: email@example.com
The title compound, C20H22Br2N2O2·0.25CH4O, was synthesized by the condensation reaction of salicylaldehyde with 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol in methanol. There are four independent main molecules and two half-occupied methanol solvent molecules in the asymmetric unit. The dihedral angles between the two benzene rings in the four molecules are 87.8 (6), 86.6 (6), 89.3 (6) and 83.1 (6)°. Each molecule features an intramolecular O-HN hydrogen bond and a short N-HBr link. In the crystal components are linked by O-HO hydrogen bonds.
For details of the pharmaceutical uses of ambroxol, systematic name 4-(2-amino-3,5-dibromobenzylamino)cyclohexanol, a compound closely related to the title compound, see: Gaida et al. (2005); Lee et al. (2004). For the structures of similar compounds, see: Wang et al. (2009, 2010). For standard bond-length data, see: Allen et al. (1987).
Data collection: SMART (Bruker, 2002); cell refinement: SAINT (Bruker, 2002); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: HB5804 ).
Financial support from the Third Affiliated Hospital of Soochow University is acknowledged.
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