3-(4-Fluorophenylsulfinyl)-5-iodo-2,7-dimethyl-1-benzofuran

In the title compound, C16H12FlO2S, the 4-fluorophenyl ring makes a dihedral angle of 80.21 (6)° with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through weak intermolecular C—H⋯O hydrogen bonds. The crystal structure also exhibits an intermolecular I⋯F contact [3.423 (2) Å].

In the title compound, C 16 H 12 FlO 2 S, the 4-fluorophenyl ring makes a dihedral angle of 80.21 (6) with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through weak intermolecular C-HÁ Á ÁO hydrogen bonds. The crystal structure also exhibits an intermolecular IÁ Á ÁF contact [3.423 (2) Å ].
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: BV2179). 3-(4-Fluorophenylsulfinyl)-5-iodo-2,7-dimethyl-1-benzofuran H. D. Choi, P. J. Seo, B. W. Son and U. Lee Comment A series of benzofuran ring system have attracted much attention owing to their interesting pharmacological properties such as antifungal, antitumor and antiviral, antimicrobial activities (Aslam et al., 2006, Galal et al., 2009, Khan et al., 2005. These compounds widely occur in nature (Akgul & Anil, 2003;Soekamto et al., 2003). As a part of our study of the substituent effect on the solid state structures of 3-(4-fluorophenylsulfinyl)-5-halo-2-methyl-1-benzofuran analogues (Choi et al., 2010a,b,c), we report here on the crystal structure of the title compound In the title molecule ( Fig. 1), the benzofuran unit is essentially planar, with a mean deviation of 0.009 (2) Å from the least-squares plane defined by the nine constituent atoms. The dihedral angle formed by the mean plane of the benzofuran fragment and the 4-fluorophenyl ring is 80.21 (6)°. The molecular packing ( Fig. 2) is stabilized by weak intermolecular C-H···O hydrogen bonds; the first one between a benzene H atom and the oxygen of the S═O unit (Table 1: C3-H3···O2 i ), and the second one between a methyl H atom and the oxygen of the S═O unit (Table 1: C9-H9A···O2 ii ), and the third one between a 4-fluorophenyl H atom and the furan O atom (Table 1; C15-H15···O1 iii ). The crystal packing (Fig. 2) is further stabilized by an I···F contact at 3.423 (2) Å [C4-I1···F1 iv = 161.10 (6) ° ].
Experimental 77% 3-chloroperoxybenzoic acid (202 mg, 0.9 mmol) was added in small portions to a stirred solution of 3-(4-fluorophenylsulfanyl)-5-iodo-2,7-dimethyl-1-benzofuran (318 mg, 0.8 mmol) in dichloromethane (40 mL) at 273 K. After being stirred at room temperature for 4h, the mixture was washed with saturated sodium bicarbonate solution and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated at reduced pressure. The residue was purified by column chromatography (hexane-ethyl acetate, 1:1 v/v) to afford the title compound as a colorless solid [yield 72%, m.p. 423-424 K; Rf = 0.65 (hexane-ethyl acetate, 1:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by slow evaporation of a solution of the title compound in acetone at room temperature.

Refinement
All H atoms were positioned geometrically and refined using a riding model, with C-H = 0.95 Å for aryl and 0.98 Å for methyl H atoms. U iso (H) =1.2U eq (C) for aryl and 1.5Ueq(C) for methyl H atoms.
supplementary materials sup-2 Figures Fig. 1. The molecular structure of the title compound with the atom numbering scheme. Displacement ellipsoids are drawn at the 50% probability level. H atoms are presented as a small spheres of arbitrary radius.

Special details
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > 2sigma(F 2 ) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger. 0.0549 (9) 0.0500 (9) 0.0437 (8) −0.0300 (8) 0.0008 (7) −0.0036 (7) O1 0.0311 (7) 0.0245 (7) 0.0302 (7