5-Chloro-3-cyclohexylsulfinyl-2,7-dimethyl-1-benzofuran

In the title compound, C16H19ClO2S, the cyclohexyl ring adopts a chair conformation and the arylsulfinyl unit is positioned equatorial relative to the cyclohexyl group. The least-squares plane through all six C atoms of the cyclohexyl ring makes a dihedral angle of 74.80 (6)° with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through intermolecular C—H⋯O hydrogen bonds.

In the title compound, C 16 H 19 ClO 2 S, the cyclohexyl ring adopts a chair conformation and the arylsulfinyl unit is positioned equatorial relative to the cyclohexyl group. The least-squares plane through all six C atoms of the cyclohexyl ring makes a dihedral angle of 74.80 (6) with the mean plane of the benzofuran fragment. In the crystal, molecules are linked through intermolecular C-HÁ Á ÁO hydrogen bonds. For natural products with benzofuran rings, see: Akgul & Anil (2003); Soekamto et al. (2003). For structural studies of related 3-cyclohexylsulfinyl-5-halo-2-methyl-1-benzofuran derivatives, see: Choi et al. (2011a,b,c Table 1 Hydrogen-bond geometry (Å , ).
In the title molecule ( Fig. 1), the benzofuran unit is essentially planar, with a mean deviation of 0.009 (1) Å from the least-squares plane defined by the nine constituent atoms. The cyclohexyl ring is in the chair form. The least-squares plane through all six C atoms of the cyclohexyl ring makes a dihedral angle of 74.80 (6)°° with the mean plane of the benzofuran fragment. The molecular packing (Fig. 2) is stabilized by intermolecular C-H···O hydrogen bonds between a cyclohexyl H atom and the O atom of the sulfinyl group (Table 1; C11-H11···O2 i ).

Experimental
77% 3-chloroperoxybenzoic acid (247 mg, 1.1 mmol) was added in small portions to a stirred solution of 5-chloro-3-cyclohexylsulfanyl-2,7-dimethyl-1-benzofuran (324 mg, 1.1 mmol) in dichloromethane (40 mL) at 273 K. After being stirred at room temperature for 4h, the mixture was washed with saturated sodium bicarbonate solution and the organic layer was separated, dried over magnesium sulfate, filtered and concentrated at reduced pressure. The residue was purified by column chromatography (hexane-ethyl acetate, 1:1 v/v) to afford the title compound as a colorless solid [yield 73%, m.p. 405-406 K; R f = 0.45 (hexane-ethyl acetate, 1:1 v/v)]. Single crystals suitable for X-ray diffraction were prepared by slow evaporation of a solution of the title compound in ethyl acetate at room temperature.

Refinement
All H atoms were positioned geometrically and refined using a riding model, with C-H = 0.95 Å for aryl, 1.00 Å for methine, 0.99 Å for methylene and 0.98 Å for methyl H atoms, respectively. U iso (H) = 1.2U eq (C) for aryl, methine, methylene, and 1.5U eq (C) for methyl H atoms.
supplementary materials sup-2 Figures Fig. 1. The molecular structure of the title compound with the atom numbering scheme. Displacement ellipsoids are drawn at the 50% probability level. H atoms are presented as a small spheres of arbitrary radius.

Special details
Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.
Refinement. Refinement of F 2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F 2 , conventional R-factors R are based on F, with F set to zero for negative F 2 . The threshold expression of F 2 > 2sigma(F 2 ) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F 2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.