Received 30 July 2011
aSchool of Pharmacy, Yantai University, Yantai 264005, People's Republic of China,bMicroscale Science Institute, Weifang University, Weifang 261041, People's Republic of China, and cSchool of Pharmacy, Binzhou Medical College, Yantai 264003, People's Republic of China
Correspondence e-mail: firstname.lastname@example.org
In the title compound, C21H22F2N6O4·0.62CH2Cl2, the difluoro-substituted benzene ring forms dihedral angles of 54.6 (3)° with the mean plane of the thymine ring and 50.9 (2)° with the triazole ring. The dihedral angle between the thymine and triazole rings is 7.4 (3)°. In the crystal, intermolecular N-HN and O-HO hydrogen bonds link the main molecules into chains along . The CH2Cl2 solvent molecule was refined as partial occupancy over two sets of sites with refined occupancies of 0.308 (9) and 0.310 (8).
For the applications of azole and triazole compounds as antifungal agents, see: Singh (2001); Richardson (2005); Hobson (2003); Slavin et al. (2002); Wingard & Leather (2004); Fridkin & Jarvis (1996); Gallis et al. (1990); Sheehan et al. (1999); Denning (2002); Aoyama et al. (1984); Lamb et al. (1999).
Data collection: SMART (Bruker, 1997); cell refinement: SAINT (Bruker, 1997); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: LH5302 ).
The authors thank Mr Lian-dong Liu (College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China) for his invaluable support in the X-ray data collection. The authors also thank the National Natural Science Foundation of China for a research grant (No. 81072534).
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