Received 31 October 2011
The title compound, C12H14BrN3O, is built up from two fused six-membered rings and one six-membered ring linked through a spiro C atom. The hydropyrimidine ring has an envelope conformation and the cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by N-HO and N-HN hydrogen bonds, forming a molecular tape along the b axis.
For medicinal and biological properties of 2,3-dihydropyrido[2,3-d]-pyrimidin-4(1H)-one derivatives, see: Parish et al. (1982); Narayana et al. (2009). For related structures, see: Shi et al. (2010); Ling et al. (2009).
Data collection: CrystalClear (Rigaku/MSC, 2009); cell refinement: CrystalClear; data reduction: CrystalClear; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: CrystalStructure (Rigaku/MSC, 2009); software used to prepare material for publication: CrystalStructure.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: IS5001 ).
The authors thank Beijing Institute of Technology for the X-ray diffraction analysis.
Narayana, B., Rao, A. R. & Rao, P. S. (2009). Eur. J. Med. Chem. 44, 1369-1376.
Ling, Z., Shi, D., Yanqiu, F., Wei, X. & Li, J. (2009). Acta Cryst. E65, o1097.
Parish, H. A. Jr, Gilliom, R. D., Purcell, W. P., Browne, R. K., Spirk, R. F. & White, H. D. (1982). J. Med. Chem. 25, 98-102.
Rigaku/MSC (2009). CrystalClear and CrystalStructure. Rigaku/MSC, The Woodlands, Texas, USA.
Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.
Shi, D., Yang, L., Tang, J., Wang, X. & Li, J. (2010). Acta Cryst. E66, o2301.