Acta Cryst. (2012). E68, o1229-o1230 [ doi:10.1107/S1600536812012561 ]
Abstract: The title compound, C34H52N2O7·CH4O, is the methanol solvate of a difunctionalized derivative of the therapeutic agent 18-glycyrrhetinic acid, a pentacyclic triterpene. The five six-membered rings of the glycyrrhetinic acid moiety show normal geometries, with four rings in chair conformations and the unsaturated ring in a half-chair conformation. This moiety is substituted by a nitrate ester group and an O-ethylglycine group. In the crystal, the nonsolvent molecules are packed parallel to (010) in a herringbone fashion with the nitrato, ethylglycine and methanol-O atom being proximate. The methanol solvent molecule is anchored via a donated O-HOacyl and an accepted N-HO hydrogen bond, giving rise to infinite zigzag chains of hydrogen bonds parallel to . Two weak intermolecular C-HO interactions to the methanol and to an acyl oxygen establish links along  and , respectively.
Online 31 March 2012
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