Acta Cryst. (2012). E68, o2357
[ doi:10.1107/S1600536812027912 ]
Abstract: Diosgenin [or (22R,25R)-spirost-5-en-3-ol] is the starting material of the Marker degradation, a cheap semi-synthesis of progesterone, which has been designated as an International Historic Chemical Landmark. Thus far, a single X-ray structure for diosgenin is known, namely its dimethyl sulfoxide solvate [Zhang et al. (2005). Acta Cryst. E61, o2324-o2325]. We have now determined the structure of the hemihydrate, C27H42O3·0.5H2O. The asymmetric unit contains two diosgenin molecules, with quite similar conformations, and one water molecule. Hydroxy groups in steroids and water molecules form O-HO hydrogen-bonded R54(10) ring motifs. Fused edge-sharing R(10) rings form a backbone oriented along , which aggregates the diosgenin molecules in the crystal structure.
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