Acta Cryst. (2012). E68, o2794
[ doi:10.1107/S160053681203632X ]
Abstract: Sitafloxacin is a newly developed fluoroquinolone antibacterial drug. The crystal studied, C19H18ClF2N3O3·CH3OH, consists of one molecule of sitafloxacin and one methanol solvent molecule. The molecule of sitafloxacin is a zwitterion with a protonated primary amine group and a deprotonated carboxylate group. The cyclopropane ring and the CO2 group make dihedral angles of 79.5 (3) and 35.4 (4)°, respectively, with the fused ring system. The supramolecular structure is defined by N-HO and O-HO hydrogen bonds.
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