Acta Crystallographica Section E

Structure Reports Online

Volume 68, Part 9 (September 2012)


organic compounds



jj2148 scheme

Acta Cryst. (2012). E68, o2757-o2758    [ doi:10.1107/S160053681203601X ]

FK228 from Burkholderia thailandensis MSMB43

X.-Y. Liu, C. Wang and Y.-Q. Cheng

Abstract: FK228 [systematic name: (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone], C24H36N4O6S2, also known as FR901228, depsipeptide, NSC 630176, romidepsin, and marketed as Istodax by Celgene Corporation, is crystallized from ethyl acetate in P21 as compared to the absolute configuration of FK228, first crystallized from methanol in P212121 [Shigematsu et al. (1994). J. Antibiot. 47, 311-314]. A slight difference is observed between the absolute configuration of FK228 and the present structure. The molecular structure is stabilized by intramolecular N-H...O hydrogen bonds. In the crystal, molecules are linked via N-H...O hydrogen bonds.


htmldisplay filedownload file

Hyper-Text Markup Language (HTML) file
[ doi:10.1107/S160053681203601X/jj2148sup0.html ]
Supplementary materials


cdxdisplay filedownload file

Chemdraw file (4.9 kbytes)
[ doi:10.1107/S160053681203601X/jj2148Isup3.cdx ]
Supplementary material


Notes:

To open or display or play some files, you may need to set your browser up to use the appropriate software. See the full list of file types for an explanation of the different file types and their related mime types and, where available links to sites from where the appropriate software may be obtained.

The download button will force most browsers to prompt for a file name to store the data on your hard disk.

Where possible, images are represented by thumbnails.

 bibliographic record in  format

  Find reference:   Volume   Page   
  Search:     From   to      Advanced search

Copyright © International Union of Crystallography
IUCr Webmaster