Received 14 October 2012
aLaboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan,bLaboratory of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan,cResearch Core for Interdisciplinary Sciences, Okayama University, Okayama 700-8530, Japan, and dDepartment of Chemistry, Faculty of Science, Okayama University, Okayama 700-8530, Japan
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In the title compound, C14H13ClN2O, the fused hydropyrimidine ring adopts an envelope conformation with one of the methylene C atoms at the flap. The three-membered ring is approximately perpendicular to the attached isoquinoline ring system, with a dihedral angle of 89.44 (11)°. In the crystal, molecules are linked by a weak C-H interaction, forming a helical chain along the c axis.
For recent reports on the development of complex heterocyclic skeletons for potential pharmaceutics in one step using the Truce-Smiles rearrangement, see: Okuda et al. (2010, 2011). For the synthesis of the title compound, see: Okuda et al. (2012).
Data collection: PROCESS-AUTO (Rigaku/MSC, 2004); cell refinement: PROCESS-AUTO; data reduction: CrystalStructure (Rigaku/MSC, 2004); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: SHELXL97 and PLATON (Spek, 2009).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: FF2085 ).
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