Received 16 September 2012
aDepartment of Chemistry, Government College University, Faisalabad 38000, Pakistan,bInstitute of Chemistry, University of the Punjab, Lahore 54590, Pakistan,cApplied Chemistry Research Center, PCSIR Laboratories Complex, Lahore 54600, Pakistan, and dDepartment of Chemistry, The University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada T2N 1N4
Correspondence e-mail: email@example.com
The asymmetric unit of the title compound, C21H22N4O4S, contains two molecules (A and B), in which the thiazine rings adopt an S-envelope conformation with the S atoms displaced by 0.621 (2) and 0.697 (2) Å from the mean planes formed by the remaining ring atoms. The dihedral angles between the N-methylacetamide groups and the methoxybenzene rings are 8.67 (10) and 54.49 (6)° in the two molecules and the equivalent torsion angles in the N-methylacetamide chains connecting the ring systems also differ. In the crystal, N-HO hydrogen bonds connect the components into C(4)  chains of alternating A and B molecules. The packing is consolidated by weak C-HO interactions, which generate a three-dimensional network.
For therapeutic applications of benzothiazines, see: Turck et al. (1996); Lombardino et al. (1973); Zinnes et al. (1973). For therapeutic applications of pyrrazoles, see: Silverstein et al. (2000). For the properties and crystal structures of related pyrazolobenzothiazine derivatives, see: Ahmad et al. (2010a,b, 2012; 2011a,b).
Data collection: APEX2 (Bruker, 2004); cell refinement: SAINT (Bruker, 2004); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997); software used to prepare material for publication: SHELXL97.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: HB6961 ).
The authors are grateful to the Higher Education Commission, Pakistan, and the Institute of Chemistry, University of the Punjab, Lahore, Pakistan, for financial support.
Ahmad, M., Siddiqui, H. L., Ahmad, S., Parvez, M. & Tizzard, G. J. (2010a). J. Chem. Crystallogr. 40, 1188-1194.
Ahmad, M., Siddiqui, H. L., Gardiner, J. M., Parvez, M. & Aslam, S. (2012). Med. Chem. Res. doi:10.1007/s00044-012-0062-6.
Ahmad, M., Siddiqui, H. L., Khattak, M. I., Ahmad, S. & Parvez, M. (2011a). Acta Cryst. E67, o216-o217.
Ahmad, M., Siddiqui, H. L., Khattak, M. I., Ahmad, S. & Parvez, M. (2011b). Acta Cryst. E67, o218-o219.
Ahmad, M., Siddiqui, H. L., Zia-ur-Rehman, M. & Parvez, M. (2010b). Eur. J. Med. Chem. 45, 698-704.
Bruker (2004). APEX2, SAINT and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA.
Farrugia, L. J. (1997). J. Appl. Cryst. 30, 565.
Lombardino, J. G., Wiseman, E. H. & Chiaini, J. (1973). J. Med. Chem. 16, 493-496.
Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.
Silverstein, F. E., Faich, G., Goldstein, J. L., Simon, L. S., Pincus, T., Whelton, A., Makuch, R., Eisen, G., Agrawal, N. M., Stenson, W. F., Burr, A. M., Zhao, W. W., Kent, J. D., Lefkowith, J. B., Verburg, K. M. & Geis, G. S. (2000). J. Am. Med. Assoc. 284, 1247-1255.
Turck, D., Roth, W. & Busch, U. (1996). Br. J. Rheumatol. 35, 13-16.
Zinnes, H., Lindo, N. A., Sircar, J. C., Schwartz, M. L. & Shavel, J. Jr (1973). J. Med. Chem. 16, 44-48.