Received 10 September 2012
The title compound (C16H22N2O6)[PtCl4]·2H2O, shows antiproliferative activity in eight tumor cell lines. The asymmetric unit consists of one solvent water molecule on a general position, and one half of each of the polyammonium cation and the tetrachloridoplatinate(II) anion, both of them located on centers of inversion. In the crystal, the cations are connected via hydrogen bonding between the carbonyl O atoms and the hydroxyl H atoms into zigzag chains that elongate in the c-axis direction. In addition, the carbonyl O atom is hydrogen-bonded to the water molecule which, in turn, interacts with the [PtCl4]2- anion. Finally, the chains are linked by N-H+Cl interactions into a three-dimensional network.
For the antitumor activity of maltol (systematic name: 3-hydroxy-2-methyl-4-pyrone) and polyamines, see: Casero & Woster (2001); Liang et al. (2006); Murakami et al. (2006). For background to the synthesis, solution behaviour, structural properties and biological activity of N,N'-bis[(3-hydroxy-4-pyron-2-yl)methyl]-N,N'-dimethylethylendiamine (Malten), see: Amatori et al. (2010, 2012).
Data collection: CrysAlis PRO (Oxford Diffraction 2009); cell refinement: CrysAlis PRO; data reduction: CrysAlis PRO; program(s) used to solve structure: SIR97 (Altomare et al., 1999); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 1997); software used to prepare material for publication: PARST97 (Nardelli, 1995).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: NC2294 ).
The authors acknowledge CRIST (Centro di Cristallografia Strutturale, University of Firenze), where the data collection was performed, and the Italian Ministero dell'Istruzione dell'Università e della Ricerca (MIUR), PRIN2009, for financial support.
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