Received 15 October 2012
In the title hydrate, C12H13NO4·H2O, the piperidine ring that is fused to the benzene ring is in a sofa conformation with the chiral C atom lying 0.4084 (18) Å out of the plane of the nine fused-ring atoms. In the crystal, O-HO and N-HO hydrogen bonds link the organic molecules and water molecules into chains running along the b-axis direction. The chains are further connected into layers parallel to the bc plane by - interactions between inversion-related benzene rings [centroid-centroid distance = 3.8846 (9) Å].
For methods of preparation of 3-alkyl- or 3-aryl-3-hydroxyquinoline-2,4-diones by oxidation of the corresponding 3-alkyl- or 3-arylquinolin-2-ones, see: Stadlbauer & Kappe (1982); Stadlbauer et al. (1992). For naturally occurring 3-hydroxyquinoline-2,4-diones, see: Neuenhaus & Budzikiewicz (1979); Luo et al. (2009). For the biological activity of 3-hydroxyquinoline-2,4-diones, see: Prisyazhnyuk et al. (1984); Luo et al. (2009). For a related structure, see: Kafka et al. (2012).
Data collection: COLLECT (Nonius, 1998); cell refinement: DENZO and SCALEPACK (Otwinowski & Minor, 1997); data reduction: DENZO and SCALEPACK; program(s) used to solve structure: SIR92 (Altomare et al., 1994); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: PLATON (Spek, 2009) and DIAMOND (Brandenburg, 1999); software used to prepare material for publication: WinGX (Farrugia, 1999).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: TK5162 ).
This study was supported by the internal grant of TBU in Zlin (No. IGA/FT/2012/043), funded from the resources of specific university research, and the Slovenian Research Agency (Project P1-0230-0103 and Joint Project BI-CZ/07-08-018). This work was also partly supported through the infrastructure of the EN-FIST Centre of Excellence, Ljubljana.
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