Acta Cryst. (2012). E68, o3385
[ doi:10.1107/S1600536812046673 ]

Dabigatran etexilate tetrahydrate

H.-Q. Liu, W.-G. Zhang, Z.-Q. Cai, W.-R. Xu and X.-P. Shen

Abstract: In the title compound, C₃₄H₄₁N₇O₅·4H₂O (systematic name: ethyl 3-{[2-({4-[(Z)-amino(hexyloxycarbonylimino)methyl]anilino}methyl)-1-methylbenzimidazole-5-carbonyl]pyridin-2-ylamino}propanoate tetrahydrate), the benzene and pyridine rings form dihedral angles of 5.4 (1) and 43.8 (1)°, respectively, with the benzimidazole mean plane. The terminal butyl group is disordered over two conformations in a 0.756 (10):0.244 (10) ratio. There is an intramolecular N-HO hydrogen bond present. In the crystal, the water molecules are involved in the formation of O-HO, O-HN and N-HO hydrogen bonds, which link the components into layers parallel to the ab plane.

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