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Acta Cryst. (2012). E68, o3352
[ doi:10.1107/S1600536812045813 ]

(S,S,S,S)-Nebivolol hydrochloride hemihydrate

Y. Rousselin, A. Bruel and A. Clavel

Abstract: The asymmetric unit of the title hydrated salt, C22H26F2NO4+·Cl-·0.5H2O, consists of an (S,S,S,S)-nebivolol {nebivol = bis[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]ammonium} cation, a chloride anion and a half-occupancy water molecule. The dihedral angle between the mean planes of the benzene rings is 50.34 (12)°. The pyran rings adopt half-chair conformations. The crystal packing features O-H...O hydrogen bonds and weak N-H...Cl, O-H...Cl, and O-H...Cl interactions, producing layers along (010).

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