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Acta Cryst. (2012). E68, o3408-o3409    [ doi:10.1107/S1600536812047137 ]

6-(4-Methoxyphenyl)naphtho[2,3-b][1]benzothiophene

V. Silambarasan, T. Srinivasan, R. Sivasakthikumaran, A. K. Mohanakrishnan and D. Velmurugan

Abstract top

The asymmetric unit of the title compound, C23H16OS, contains two independent molecules with opposite orientations of the methoxy groups bonded to the benzene rings. The napthobenzothiophene group in the two molecules is separated by an average distance of 3.912 Å. In both molecules, the napthobenzothiophene unit is almost planar, with r.m.s deviations of 0.0522 and 0.0143 Å. The methoxyphenyl ring makes dihedral angles of 67.0 (6)° and 70.4 (6)° with respect to the napthobenzothiophene ring system in the two molecules. The crystal packing features C-H...S, [pi]-[pi] [centroid-centroid distances = 3.666 (10) and 3.658 (10) Å] and C-H...[pi] interactions, forming a sheet running along the b-axis direction.

Comment top

Thiophene derivatives exhibit anti-Human immunodeficiency virus protease (HIVPR) (Bonini et al., 2005) and anti-breast cancer (Brault et al., 2005) activities. In addition, some of the benzo[b]thiophene derivatives show significant antimicrobial and anti-inflammatory activities (Isloora et al., 2010). The thiophene derivatives have been viewed as significant compounds for application in many fields (Xia et al., 2010). In order to obtain detailed information on molecular conformations in the solid state, X-ray crystallographic study of the title compound was carried out.

An asymmetric unit of the title compound contains two crystallographically independent molecules with opposite orientations of the methoxy groups (Fig. 1). The bond lengths and angles agree with those observed in another benzothiophene derivative (Gunasekaran et al., 2010). In both the molecules, napthobenzothiophene ring system is essentially planar, with maximum deviation of 0.103 (2) and 0.024 (1) Å for atoms C21 and S1', respectively. In both molecules, the napthobenzothiophene ring system (S1/C8—C23 and S1'/C8'-C23') makes dihedral angles of 67.0 (6)° and 70.4 (6)° with respect to benzene rings (C2–C7) and (C2'–C7'), respectively; showing that both the ring system are almost perpendicular to each other.

The π···π electron interactions are observed between the thiophene ring (S1/C16—C19 [at x, y, z] and the benzene ring (C9—C14) [at -1 + x, y, z] with centroid-centroid distance 3.666 (10) Å and between the thiophene ring (S1'/C16'–C19' [at x, y, z] and the benzene ring (C9'–C14') [at 1 + x, y, z] with the centroid-centroid distance 3.658 (10) Å. In addition the crystal packing is stabilized by C–H···S and C–H···π (Table. 1) types of interactions.

Related literature top

For the biological activity of thiophene derivatives, see: Bonini et al. (2005); Brault et al. (2005); Isloora et al. (2010); Xia et al. (2010). For a related structure, see: Gunasekaran et al. (2010).

Experimental top

Benzo[b]thiophen-3-yl(2-((4-methoxyphenyl)pivaloyloxy)methyl)phenyl)methyl pivalate (0.73 g, 1.60 mmol) upon interaction with ZnBr2 (0.02 g, 0.13 mmol) followed by removal of solvent and column chromatographic purification (silica gel; hexane-ethyl acetate, 99:1) gave the compound as a colorless solid (0.50 g, 72%); the compound was recrystalized from chloroform.

Refinement top

All H atoms were fixed geometrically and allowed to ride on their parent C atoms, with C—H distances 0.93 and 0.96 Å for aryl and methyl H-atoms with Uiso(H) = 1.5Ueq(methyl-C) and 1.2Ueq(aryl-C).

Computing details top

Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT (Bruker, 2008); program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 (Farrugia, 2012); software used to prepare material for publication: SHELXL97 (Sheldrick, 2008) and PLATON (Spek, 2009).

Figures top
[Figure 1] Fig. 1. The molecular structure of the title compound with the atom numbering scheme. Displacement ellipsoids are drawn at the 30% probability level. H atoms are presented as small spheres of arbitrary radius.
[Figure 2] Fig. 2. A view of the C—-H···π interactions (dotted lines) in the crystal structure of the title compound. H atoms non-participating in hydrogen-bonding were omitted for clarity.
6-(4-Methoxyphenyl)naphtho[2,3-b][1]benzothiophene top
Crystal data top
C23H16OSZ = 4
Mr = 340.42F(000) = 712
Triclinic, P1Dx = 1.343 Mg m−3
Hall symbol: -P 1Mo Kα radiation, λ = 0.71073 Å
a = 6.2019 (3) ÅCell parameters from 8440 reflections
b = 11.2124 (6) Åθ = 0.8–28.5°
c = 24.4724 (13) ŵ = 0.20 mm−1
α = 95.759 (3)°T = 293 K
β = 91.762 (3)°Block, colourless
γ = 95.617 (3)°0.20 × 0.20 × 0.20 mm
V = 1683.63 (15) Å3
Data collection top
Bruker SMART APEXII area-detector
diffractometer		8440 independent reflections
Radiation source: fine-focus sealed tube6029 reflections with I > 2σ(I)
Graphite monochromatorRint = 0.041
ω and φ scansθmax = 28.5°, θmin = 0.8°
Absorption correction: multi-scan
(SADABS; Bruker, 2008)		h = −8→8
Tmin = 0.981, Tmax = 0.985k = −14→15
30236 measured reflectionsl = −32→32
Refinement top
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.046Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.140H-atom parameters constrained
S = 1.03 w = 1/[σ2(Fo2) + (0.0729P)2 + 0.216P]
where P = (Fo2 + 2Fc2)/3
8440 reflections(Δ/σ)max = 0.001
451 parametersΔρmax = 0.37 e Å−3
0 restraintsΔρmin = −0.28 e Å−3
Crystal data top
C23H16OSγ = 95.617 (3)°
Mr = 340.42V = 1683.63 (15) Å3
Triclinic, P1Z = 4
a = 6.2019 (3) ÅMo Kα radiation
b = 11.2124 (6) ŵ = 0.20 mm−1
c = 24.4724 (13) ÅT = 293 K
α = 95.759 (3)°0.20 × 0.20 × 0.20 mm
β = 91.762 (3)°
Data collection top
Bruker SMART APEXII area-detector
diffractometer		8440 independent reflections
Absorption correction: multi-scan
(SADABS; Bruker, 2008)		6029 reflections with I > 2σ(I)
Tmin = 0.981, Tmax = 0.985Rint = 0.041
30236 measured reflectionsθmax = 28.5°
Refinement top
R[F2 > 2σ(F2)] = 0.046H-atom parameters constrained
wR(F2) = 0.140Δρmax = 0.37 e Å−3
S = 1.03Δρmin = −0.28 e Å−3
8440 reflectionsAbsolute structure: ?
451 parametersFlack parameter: ?
0 restraintsRogers parameter: ?
Special details top

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

Fractional atomic coordinates and isotropic or equivalent isotropic displacement parameters (Å2) top
xyzUiso*/Ueq
S10.18748 (7)0.11396 (4)0.544498 (16)0.04374 (13)
S1'0.32902 (7)0.37462 (4)0.961647 (16)0.04379 (13)
O10.4892 (2)0.28907 (12)0.32371 (5)0.0549 (3)
O1'−0.0436 (2)0.23774 (13)1.18636 (5)0.0575 (3)
C170.4236 (2)0.19074 (14)0.57740 (6)0.0373 (3)
C8'−0.0574 (2)0.22460 (14)0.95470 (6)0.0366 (3)
C180.2493 (3)0.09979 (14)0.65053 (6)0.0400 (4)
C16'0.1203 (2)0.27619 (14)0.87037 (6)0.0379 (3)
C90.7591 (2)0.31808 (14)0.58557 (7)0.0403 (4)
C5'−0.0552 (2)0.23189 (14)1.01597 (6)0.0365 (3)
C17'0.1090 (2)0.28311 (14)0.92850 (6)0.0363 (3)
C80.5807 (2)0.25893 (14)0.55212 (6)0.0385 (3)
C18'0.3128 (3)0.34510 (14)0.85358 (6)0.0396 (4)
C160.4363 (2)0.17469 (14)0.63429 (6)0.0391 (3)
C190.1000 (3)0.06293 (14)0.60615 (6)0.0405 (4)
C14'−0.2168 (3)0.14796 (14)0.86256 (6)0.0396 (4)
C20.5044 (3)0.28681 (15)0.37968 (7)0.0409 (4)
C15'−0.0416 (3)0.20851 (15)0.83843 (6)0.0416 (4)
H15'−0.03520.20270.80030.050*
C150.6110 (3)0.22988 (15)0.66590 (7)0.0443 (4)
H150.62160.21920.70310.053*
C4'0.0925 (3)0.17389 (16)1.04479 (6)0.0449 (4)
H4'0.19280.13141.02560.054*
C50.5587 (2)0.27062 (14)0.49206 (6)0.0376 (3)
C19'0.4407 (3)0.40253 (15)0.89885 (7)0.0417 (4)
C40.3946 (3)0.33000 (17)0.47121 (7)0.0495 (4)
H40.30050.36520.49530.059*
C9'−0.2270 (2)0.15599 (14)0.92128 (6)0.0377 (3)
C70.6709 (3)0.22705 (16)0.39932 (7)0.0467 (4)
H70.76430.19200.37500.056*
C140.7746 (3)0.30247 (15)0.64273 (7)0.0426 (4)
C20−0.0950 (3)−0.00424 (15)0.61356 (7)0.0482 (4)
H20−0.1941−0.02730.58420.058*
C130.9558 (3)0.36222 (18)0.67486 (8)0.0549 (5)
H130.96790.35200.71200.066*
C23'0.3812 (3)0.35939 (16)0.80082 (7)0.0490 (4)
H23'0.29760.32280.77040.059*
C3'0.0937 (3)0.17794 (17)1.10136 (7)0.0475 (4)
H3'0.19410.13861.11990.057*
C60.6984 (3)0.21946 (16)0.45486 (7)0.0459 (4)
H60.81140.17980.46780.055*
C2'−0.0545 (3)0.24060 (15)1.13040 (6)0.0418 (4)
C7'−0.2004 (3)0.30002 (17)1.10305 (7)0.0508 (4)
H7'−0.29900.34331.12250.061*
C6'−0.1999 (3)0.29510 (17)1.04629 (7)0.0505 (4)
H6'−0.29960.33541.02800.061*
C30.3662 (3)0.33868 (17)0.41563 (7)0.0496 (4)
H30.25450.37930.40260.060*
C230.2027 (3)0.06416 (16)0.70203 (7)0.0496 (4)
H230.30130.08610.73160.059*
C100.9248 (3)0.39496 (16)0.56390 (8)0.0479 (4)
H100.91710.40690.52690.057*
C220.0102 (3)−0.00373 (17)0.70930 (8)0.0565 (5)
H22−0.0203−0.02800.74370.068*
C13'−0.3877 (3)0.07889 (16)0.83011 (7)0.0481 (4)
H13'−0.38150.07220.79200.058*
C11'−0.5702 (3)0.03041 (17)0.91091 (8)0.0504 (4)
H11'−0.6884−0.00840.92670.060*
C12'−0.5596 (3)0.02260 (17)0.85331 (7)0.0520 (4)
H12'−0.6705−0.02120.83120.062*
C10'−0.4088 (3)0.09435 (15)0.94365 (7)0.0433 (4)
H10'−0.41800.09770.98160.052*
C111.0943 (3)0.45122 (17)0.59649 (9)0.0580 (5)
H111.19990.50170.58160.070*
C21−0.1387 (3)−0.03607 (17)0.66532 (8)0.0543 (5)
H21−0.2699−0.07990.67100.065*
C20'0.6349 (3)0.47103 (17)0.89157 (8)0.0534 (4)
H20'0.72000.50790.92170.064*
C21'0.6986 (3)0.48325 (18)0.83907 (8)0.0613 (5)
H21'0.82780.52920.83370.074*
C121.1107 (3)0.43343 (19)0.65267 (9)0.0609 (5)
H121.22840.47080.67450.073*
C10.3082 (4)0.3402 (2)0.30222 (8)0.0734 (6)
H1A0.31460.33700.26300.110*
H1B0.31090.42260.31760.110*
H1C0.17670.29570.31160.110*
C22'0.5729 (3)0.42791 (17)0.79378 (8)0.0575 (5)
H22'0.61880.43730.75850.069*
C1'−0.2057 (4)0.2910 (2)1.21743 (8)0.0775 (7)
H1D−0.18000.28271.25570.116*
H1E−0.34580.25131.20540.116*
H1F−0.20080.37491.21210.116*
Atomic displacement parameters (Å2) top
U11U22U33U12U13U23
S10.0432 (2)0.0465 (3)0.0395 (2)−0.00126 (18)−0.00526 (17)0.00235 (18)
S1'0.0431 (2)0.0492 (3)0.0362 (2)−0.00239 (18)−0.00513 (16)−0.00047 (17)
O10.0586 (8)0.0671 (9)0.0408 (7)0.0062 (6)0.0047 (5)0.0143 (6)
O1'0.0621 (8)0.0789 (9)0.0316 (6)0.0090 (7)0.0024 (5)0.0037 (6)
C170.0372 (8)0.0355 (8)0.0382 (8)0.0045 (6)−0.0021 (6)−0.0011 (6)
C8'0.0397 (8)0.0376 (8)0.0327 (8)0.0067 (6)−0.0027 (6)0.0041 (6)
C180.0427 (8)0.0362 (8)0.0401 (9)0.0034 (7)0.0015 (7)−0.0002 (7)
C16'0.0409 (8)0.0374 (8)0.0352 (8)0.0036 (7)−0.0021 (6)0.0048 (6)
C90.0374 (8)0.0370 (8)0.0456 (9)0.0069 (7)0.0031 (7)−0.0035 (7)
C5'0.0387 (8)0.0381 (8)0.0322 (7)0.0020 (7)−0.0019 (6)0.0034 (6)
C17'0.0386 (8)0.0354 (8)0.0343 (8)0.0037 (6)−0.0055 (6)0.0025 (6)
C80.0390 (8)0.0360 (8)0.0399 (8)0.0070 (7)0.0018 (6)−0.0015 (6)
C18'0.0424 (8)0.0377 (8)0.0383 (8)0.0026 (7)−0.0006 (6)0.0043 (7)
C160.0405 (8)0.0380 (9)0.0380 (8)0.0048 (7)−0.0007 (6)−0.0001 (6)
C190.0445 (9)0.0352 (8)0.0411 (9)0.0059 (7)0.0004 (7)−0.0013 (7)
C14'0.0418 (8)0.0401 (9)0.0362 (8)0.0027 (7)−0.0050 (6)0.0038 (7)
C20.0430 (9)0.0386 (9)0.0406 (9)−0.0018 (7)0.0042 (7)0.0064 (7)
C15'0.0463 (9)0.0460 (9)0.0314 (8)0.0005 (7)−0.0043 (6)0.0038 (7)
C150.0469 (9)0.0473 (10)0.0373 (8)0.0038 (7)−0.0034 (7)0.0002 (7)
C4'0.0432 (9)0.0561 (10)0.0381 (9)0.0164 (8)0.0033 (7)0.0070 (7)
C50.0390 (8)0.0347 (8)0.0386 (8)0.0033 (6)0.0036 (6)0.0015 (6)
C19'0.0444 (9)0.0380 (9)0.0420 (9)0.0037 (7)0.0008 (7)0.0017 (7)
C40.0477 (10)0.0571 (11)0.0468 (10)0.0209 (8)0.0104 (7)0.0035 (8)
C9'0.0391 (8)0.0374 (8)0.0365 (8)0.0046 (7)−0.0023 (6)0.0045 (6)
C70.0491 (10)0.0481 (10)0.0445 (9)0.0137 (8)0.0104 (7)0.0016 (7)
C140.0372 (8)0.0418 (9)0.0470 (9)0.0044 (7)−0.0011 (7)−0.0044 (7)
C200.0467 (9)0.0414 (9)0.0533 (10)−0.0001 (7)−0.0016 (8)−0.0039 (8)
C130.0462 (10)0.0618 (12)0.0528 (11)0.0027 (9)−0.0070 (8)−0.0079 (9)
C23'0.0589 (11)0.0468 (10)0.0402 (9)−0.0012 (8)0.0021 (8)0.0055 (7)
C3'0.0473 (9)0.0592 (11)0.0393 (9)0.0156 (8)−0.0016 (7)0.0116 (8)
C60.0454 (9)0.0477 (10)0.0464 (10)0.0150 (8)0.0044 (7)0.0036 (7)
C2'0.0444 (9)0.0470 (10)0.0323 (8)−0.0013 (7)−0.0008 (6)0.0022 (7)
C7'0.0535 (10)0.0595 (11)0.0403 (9)0.0213 (9)0.0029 (7)−0.0054 (8)
C6'0.0556 (10)0.0567 (11)0.0417 (9)0.0230 (9)−0.0063 (8)0.0023 (8)
C30.0461 (9)0.0562 (11)0.0504 (10)0.0171 (8)0.0031 (8)0.0123 (8)
C230.0557 (10)0.0489 (10)0.0424 (9)−0.0005 (8)−0.0003 (8)0.0028 (8)
C100.0443 (9)0.0425 (10)0.0548 (10)0.0016 (7)0.0081 (8)−0.0041 (8)
C220.0700 (13)0.0509 (11)0.0473 (10)−0.0030 (9)0.0104 (9)0.0056 (8)
C13'0.0527 (10)0.0498 (10)0.0394 (9)0.0000 (8)−0.0094 (7)0.0017 (7)
C11'0.0430 (9)0.0490 (10)0.0577 (11)−0.0039 (8)0.0012 (8)0.0069 (8)
C12'0.0479 (10)0.0497 (10)0.0546 (11)−0.0049 (8)−0.0120 (8)0.0007 (8)
C10'0.0456 (9)0.0434 (9)0.0405 (9)0.0020 (7)0.0022 (7)0.0047 (7)
C110.0439 (10)0.0475 (11)0.0772 (14)−0.0067 (8)0.0115 (9)−0.0115 (9)
C210.0525 (10)0.0458 (10)0.0617 (12)−0.0067 (8)0.0103 (9)0.0003 (9)
C20'0.0503 (10)0.0515 (11)0.0536 (11)−0.0071 (8)0.0015 (8)−0.0051 (8)
C21'0.0619 (12)0.0534 (12)0.0642 (13)−0.0136 (9)0.0148 (10)−0.0004 (9)
C120.0405 (10)0.0631 (13)0.0722 (14)−0.0043 (9)−0.0046 (9)−0.0160 (10)
C10.0792 (15)0.0909 (17)0.0565 (12)0.0178 (13)−0.0037 (11)0.0322 (11)
C22'0.0682 (13)0.0526 (11)0.0505 (11)−0.0058 (9)0.0151 (9)0.0076 (9)
C1'0.0793 (15)0.112 (2)0.0405 (11)0.0155 (14)0.0159 (10)−0.0067 (11)
Geometric parameters (Å, º) top
S1—C191.7494 (17)C7—C61.377 (2)
S1—C171.7540 (15)C7—H70.9300
S1'—C19'1.7488 (17)C14—C131.422 (2)
S1'—C17'1.7504 (15)C20—C211.378 (3)
O1—C21.3729 (19)C20—H200.9300
O1—C11.420 (2)C13—C121.351 (3)
O1'—C2'1.3727 (18)C13—H130.9300
O1'—C1'1.421 (2)C23'—C22'1.377 (3)
C17—C81.379 (2)C23'—H23'0.9300
C17—C161.422 (2)C3'—C2'1.382 (2)
C8'—C17'1.378 (2)C3'—H3'0.9300
C8'—C9'1.425 (2)C6—H60.9300
C8'—C5'1.493 (2)C2'—C7'1.371 (2)
C18—C231.390 (2)C7'—C6'1.385 (2)
C18—C191.407 (2)C7'—H7'0.9300
C18—C161.454 (2)C6'—H6'0.9300
C16'—C15'1.371 (2)C3—H30.9300
C16'—C17'1.421 (2)C23—C221.378 (3)
C16'—C18'1.451 (2)C23—H230.9300
C9—C81.423 (2)C10—C111.363 (2)
C9—C101.426 (2)C10—H100.9300
C9—C141.428 (2)C22—C211.392 (3)
C5'—C6'1.385 (2)C22—H220.9300
C5'—C4'1.389 (2)C13'—C12'1.354 (3)
C8—C51.492 (2)C13'—H13'0.9300
C18'—C23'1.391 (2)C11'—C10'1.361 (2)
C18'—C19'1.405 (2)C11'—C12'1.408 (2)
C16—C151.370 (2)C11'—H11'0.9300
C19—C201.388 (2)C12'—H12'0.9300
C14'—C15'1.402 (2)C10'—H10'0.9300
C14'—C13'1.421 (2)C11—C121.411 (3)
C14'—C9'1.434 (2)C11—H110.9300
C2—C31.374 (2)C21—H210.9300
C2—C71.384 (2)C20'—C21'1.372 (3)
C15'—H15'0.9300C20'—H20'0.9300
C15—C141.407 (2)C21'—C22'1.391 (3)
C15—H150.9300C21'—H21'0.9300
C4'—C3'1.380 (2)C12—H120.9300
C4'—H4'0.9300C1—H1A0.9600
C5—C41.381 (2)C1—H1B0.9600
C5—C61.396 (2)C1—H1C0.9600
C19'—C20'1.390 (2)C22'—H22'0.9300
C4—C31.381 (2)C1'—H1D0.9600
C4—H40.9300C1'—H1E0.9600
C9'—C10'1.418 (2)C1'—H1F0.9600
C19—S1—C1791.55 (7)C12—C13—H13119.2
C19'—S1'—C17'91.64 (7)C14—C13—H13119.2
C2—O1—C1116.84 (14)C22'—C23'—C18'119.79 (17)
C2'—O1'—C1'117.75 (15)C22'—C23'—H23'120.1
C8—C17—C16123.04 (14)C18'—C23'—H23'120.1
C8—C17—S1125.08 (12)C4'—C3'—C2'119.88 (14)
C16—C17—S1111.88 (12)C4'—C3'—H3'120.1
C17'—C8'—C9'117.64 (13)C2'—C3'—H3'120.1
C17'—C8'—C5'120.48 (13)C7—C6—C5120.82 (15)
C9'—C8'—C5'121.87 (14)C7—C6—H6119.6
C23—C18—C19119.04 (16)C5—C6—H6119.6
C23—C18—C16129.04 (15)C7'—C2'—O1'124.30 (15)
C19—C18—C16111.91 (14)C7'—C2'—C3'119.98 (15)
C15'—C16'—C17'118.90 (15)O1'—C2'—C3'115.73 (14)
C15'—C16'—C18'129.10 (14)C2'—C7'—C6'119.51 (16)
C17'—C16'—C18'112.00 (13)C2'—C7'—H7'120.2
C8—C9—C10121.87 (16)C6'—C7'—H7'120.2
C8—C9—C14120.09 (15)C7'—C6'—C5'121.90 (15)
C10—C9—C14118.04 (15)C7'—C6'—H6'119.0
C6'—C5'—C4'117.34 (14)C5'—C6'—H6'119.0
C6'—C5'—C8'121.91 (13)C2—C3—C4119.38 (15)
C4'—C5'—C8'120.75 (14)C2—C3—H3120.3
C8'—C17'—C16'123.19 (14)C4—C3—H3120.3
C8'—C17'—S1'125.00 (11)C22—C23—C18119.95 (16)
C16'—C17'—S1'111.81 (12)C22—C23—H23120.0
C17—C8—C9117.52 (14)C18—C23—H23120.0
C17—C8—C5120.25 (14)C11—C10—C9121.17 (18)
C9—C8—C5122.22 (14)C11—C10—H10119.4
C23'—C18'—C19'119.03 (16)C9—C10—H10119.4
C23'—C18'—C16'128.98 (15)C23—C22—C21120.23 (17)
C19'—C18'—C16'112.00 (14)C23—C22—H22119.9
C15—C16—C17118.98 (15)C21—C22—H22119.9
C15—C16—C18129.06 (15)C12'—C13'—C14'121.58 (16)
C17—C16—C18111.94 (13)C12'—C13'—H13'119.2
C20—C19—C18121.03 (16)C14'—C13'—H13'119.2
C20—C19—S1126.27 (13)C10'—C11'—C12'120.47 (17)
C18—C19—S1112.68 (13)C10'—C11'—H11'119.8
C15'—C14'—C13'121.48 (14)C12'—C11'—H11'119.8
C15'—C14'—C9'119.94 (14)C13'—C12'—C11'119.97 (16)
C13'—C14'—C9'118.58 (15)C13'—C12'—H12'120.0
O1—C2—C3124.11 (15)C11'—C12'—H12'120.0
O1—C2—C7115.89 (15)C11'—C10'—C9'121.62 (16)
C3—C2—C7120.00 (15)C11'—C10'—H10'119.2
C16'—C15'—C14'120.69 (14)C9'—C10'—H10'119.2
C16'—C15'—H15'119.7C10—C11—C12120.43 (18)
C14'—C15'—H15'119.7C10—C11—H11119.8
C16—C15—C14120.67 (15)C12—C11—H11119.8
C16—C15—H15119.7C20—C21—C22121.10 (17)
C14—C15—H15119.7C20—C21—H21119.5
C3'—C4'—C5'121.38 (15)C22—C21—H21119.5
C3'—C4'—H4'119.3C21'—C20'—C19'118.71 (17)
C5'—C4'—H4'119.3C21'—C20'—H20'120.6
C4—C5—C6117.68 (15)C19'—C20'—H20'120.6
C4—C5—C8120.80 (14)C20'—C21'—C22'121.02 (18)
C6—C5—C8121.50 (14)C20'—C21'—H21'119.5
C20'—C19'—C18'121.00 (16)C22'—C21'—H21'119.5
C20'—C19'—S1'126.44 (13)C13—C12—C11120.16 (17)
C18'—C19'—S1'112.55 (13)C13—C12—H12119.9
C3—C4—C5122.00 (15)C11—C12—H12119.9
C3—C4—H4119.0O1—C1—H1A109.5
C5—C4—H4119.0O1—C1—H1B109.5
C10'—C9'—C8'122.62 (14)H1A—C1—H1B109.5
C10'—C9'—C14'117.76 (14)O1—C1—H1C109.5
C8'—C9'—C14'119.62 (14)H1A—C1—H1C109.5
C6—C7—C2120.11 (15)H1B—C1—H1C109.5
C6—C7—H7119.9C23'—C22'—C21'120.46 (18)
C2—C7—H7119.9C23'—C22'—H22'119.8
C15—C14—C13121.72 (16)C21'—C22'—H22'119.8
C15—C14—C9119.66 (14)O1'—C1'—H1D109.5
C13—C14—C9118.61 (16)O1'—C1'—H1E109.5
C21—C20—C19118.60 (16)H1D—C1'—H1E109.5
C21—C20—H20120.7O1'—C1'—H1F109.5
C19—C20—H20120.7H1D—C1'—H1F109.5
C12—C13—C14121.57 (18)H1E—C1'—H1F109.5
C19—S1—C17—C8−178.68 (14)C6—C5—C4—C30.5 (3)
C19—S1—C17—C161.36 (12)C8—C5—C4—C3−177.81 (16)
C17'—C8'—C5'—C6'110.27 (19)C17'—C8'—C9'—C10'−178.49 (14)
C9'—C8'—C5'—C6'−70.9 (2)C5'—C8'—C9'—C10'2.7 (2)
C17'—C8'—C5'—C4'−70.3 (2)C17'—C8'—C9'—C14'1.4 (2)
C9'—C8'—C5'—C4'108.46 (18)C5'—C8'—C9'—C14'−177.45 (13)
C9'—C8'—C17'—C16'−1.2 (2)C15'—C14'—C9'—C10'179.21 (15)
C5'—C8'—C17'—C16'177.68 (14)C13'—C14'—C9'—C10'−0.2 (2)
C9'—C8'—C17'—S1'178.44 (11)C15'—C14'—C9'—C8'−0.7 (2)
C5'—C8'—C17'—S1'−2.7 (2)C13'—C14'—C9'—C8'179.93 (14)
C15'—C16'—C17'—C8'0.2 (2)O1—C2—C7—C6−179.65 (15)
C18'—C16'—C17'—C8'−179.42 (14)C3—C2—C7—C60.0 (3)
C15'—C16'—C17'—S1'−179.48 (12)C16—C15—C14—C13178.99 (16)
C18'—C16'—C17'—S1'0.93 (17)C16—C15—C14—C9−0.5 (2)
C19'—S1'—C17'—C8'179.39 (14)C8—C9—C14—C15−1.0 (2)
C19'—S1'—C17'—C16'−0.96 (12)C10—C9—C14—C15178.29 (15)
C16—C17—C8—C9−1.9 (2)C8—C9—C14—C13179.57 (15)
S1—C17—C8—C9178.17 (11)C10—C9—C14—C13−1.2 (2)
C16—C17—C8—C5179.16 (13)C18—C19—C20—C21−1.0 (2)
S1—C17—C8—C5−0.8 (2)S1—C19—C20—C21−179.45 (13)
C10—C9—C8—C17−177.15 (14)C15—C14—C13—C12−178.89 (17)
C14—C9—C8—C172.1 (2)C9—C14—C13—C120.6 (3)
C10—C9—C8—C51.8 (2)C19'—C18'—C23'—C22'0.8 (3)
C14—C9—C8—C5−178.99 (14)C16'—C18'—C23'—C22'−178.97 (17)
C15'—C16'—C18'—C23'−0.2 (3)C5'—C4'—C3'—C2'0.1 (3)
C17'—C16'—C18'—C23'179.39 (16)C2—C7—C6—C50.6 (3)
C15'—C16'—C18'—C19'−179.90 (16)C4—C5—C6—C7−0.8 (3)
C17'—C16'—C18'—C19'−0.36 (19)C8—C5—C6—C7177.49 (16)
C8—C17—C16—C150.5 (2)C1'—O1'—C2'—C7'5.7 (3)
S1—C17—C16—C15−179.53 (12)C1'—O1'—C2'—C3'−174.10 (18)
C8—C17—C16—C18179.50 (14)C4'—C3'—C2'—C7'−0.9 (3)
S1—C17—C16—C18−0.55 (16)C4'—C3'—C2'—O1'178.84 (16)
C23—C18—C16—C15−1.0 (3)O1'—C2'—C7'—C6'−178.77 (17)
C19—C18—C16—C15178.00 (16)C3'—C2'—C7'—C6'1.0 (3)
C23—C18—C16—C17−179.85 (16)C2'—C7'—C6'—C5'−0.2 (3)
C19—C18—C16—C17−0.85 (19)C4'—C5'—C6'—C7'−0.6 (3)
C23—C18—C19—C202.4 (2)C8'—C5'—C6'—C7'178.79 (17)
C16—C18—C19—C20−176.73 (14)O1—C2—C3—C4179.32 (16)
C23—C18—C19—S1−179.00 (13)C7—C2—C3—C4−0.3 (3)
C16—C18—C19—S11.89 (17)C5—C4—C3—C20.1 (3)
C17—S1—C19—C20176.66 (15)C19—C18—C23—C22−1.6 (3)
C17—S1—C19—C18−1.87 (12)C16—C18—C23—C22177.35 (17)
C1—O1—C2—C3−5.2 (3)C8—C9—C10—C11179.81 (15)
C1—O1—C2—C7174.46 (17)C14—C9—C10—C110.6 (2)
C17'—C16'—C15'—C14'0.6 (2)C18—C23—C22—C21−0.5 (3)
C18'—C16'—C15'—C14'−179.88 (15)C15'—C14'—C13'—C12'−178.44 (16)
C13'—C14'—C15'—C16'179.04 (15)C9'—C14'—C13'—C12'1.0 (3)
C9'—C14'—C15'—C16'−0.4 (2)C14'—C13'—C12'—C11'−0.9 (3)
C17—C16—C15—C140.7 (2)C10'—C11'—C12'—C13'0.1 (3)
C18—C16—C15—C14−178.09 (15)C12'—C11'—C10'—C9'0.7 (3)
C6'—C5'—C4'—C3'0.7 (3)C8'—C9'—C10'—C11'179.25 (15)
C8'—C5'—C4'—C3'−178.74 (16)C14'—C9'—C10'—C11'−0.6 (2)
C17—C8—C5—C466.3 (2)C9—C10—C11—C120.7 (3)
C9—C8—C5—C4−112.60 (19)C19—C20—C21—C22−1.1 (3)
C17—C8—C5—C6−111.91 (18)C23—C22—C21—C201.9 (3)
C9—C8—C5—C669.2 (2)C18'—C19'—C20'—C21'1.0 (3)
C23'—C18'—C19'—C20'−1.2 (2)S1'—C19'—C20'—C21'179.79 (15)
C16'—C18'—C19'—C20'178.60 (15)C19'—C20'—C21'—C22'−0.4 (3)
C23'—C18'—C19'—S1'179.85 (13)C14—C13—C12—C110.7 (3)
C16'—C18'—C19'—S1'−0.37 (18)C10—C11—C12—C13−1.3 (3)
C17'—S1'—C19'—C20'−178.14 (16)C18'—C23'—C22'—C21'−0.2 (3)
C17'—S1'—C19'—C18'0.76 (13)C20'—C21'—C22'—C23'0.0 (3)
Hydrogen-bond geometry (Å, º) top
Cg2, Cg5 and Cg15 are the centroids of the C2–C7, C18–C23 and C9'–C14' rings, respectively.
D—H···AD—HH···AD···AD—H···A
C6′—H6′···S1′i0.932.873.7591 (17)160
C3′—H3′···Cg15ii0.932.933.704 (2)141
C7—H7···Cg5iii0.932.893.672 (2)143
C11—H11···Cg2iv0.932.913.789 (2)159
Symmetry codes: (i) x−1, y, z; (ii) −x, −y, −z+2; (iii) −x+1, −y, −z+1; (iv) −x+2, −y+1, −z+1.
Hydrogen-bond geometry (Å, º) top
Cg2, Cg5 and Cg15 are the centroids of the C2–C7, C18–C23 and C9'–C14' rings, respectively.
D—H···AD—HH···AD···AD—H···A
C6'—H6'···S1'i0.932.873.7591 (17)159.9
C3'—H3'···Cg15ii0.932.933.704 (2)141
C7—H7···Cg5iii0.932.893.672 (2)143
C11—H11···Cg2iv0.932.913.789 (2)159
Symmetry codes: (i) x−1, y, z; (ii) −x, −y, −z+2; (iii) −x+1, −y, −z+1; (iv) −x+2, −y+1, −z+1.
Acknowledgements top

The authors thank the TBI X-ray facility, CAS in Crystallography and Biophysics, University of Madras, India, for the data collection and VS and DV also thank the UGC SAP for financial support.

references
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