Received 16 December 2012
aDepartment of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119991, Russian Federation,bInstitute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka 142432, Moscow Region, Russian Federation, and cInstitute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii prosp. 31, Moscow 119991, Russian Federation
Correspondence e-mail: email@example.com
In the title compound, C16H15F3N2O4, the relative stereochemistry of the four stereogenic C atoms has been determined. The carboxymethyl and 2-(trifluoromethyl)phenyl substituents of the pyrrolidine cycle have a cis mutual arrangement. The five-membered saturated azacycle adopts an envelope conformation with the N atom occupying the flap position. In the crystal, adjacent molecules are combined in centrosymmetric dimers by two weak N-HO hydrogen bonds.
For general background to the chemistry affording bicyclic pyrrolo[3,4-c]pyrrole-based scaffolds and structural determination, see: Kudryavtsev & Irkha (2005); Kudryavtsev (2008); Kudryavtsev & Zagulyaeva (2008); Kudryavtsev et al. (2011).
Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXTL (Sheldrick, 2008); program(s) used to refine structure: SHELXTL; molecular graphics: SHELXTL; software used to prepare material for publication: SHELXTL.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: FF2094 ).
This study was partially supported by the Russian Foundation for Basic Research (project Nos 11-03-00630_a, 11-03-91375-ST_a and 12-03-92005-NNS_a).
Bruker (2008). APEX2, SADABS and SAINT. Bruker AXS Inc., Madison, Wisconsin, USA.
Kudryavtsev, K. V. (2008). Russ. Chem. Bull. 57, 2364-2372.
Kudryavtsev, K. V., Churakov, A. V. & Dogan, O. (2011). Acta Cryst. E67, o3186.
Kudryavtsev, K. V. & Irkha, V. V. (2005). Molecules, 10, 755-761.
Kudryavtsev, K. V. & Zagulyaeva, A. A. (2008). Russ. J. Org. Chem. 44, 378-387.
Sheldrick, G. M. (2008). Acta Cryst. A64, 112-122.