Acta Cryst. (2013). E69, o410-o411
[ doi:10.1107/S1600536813003954 ]

Stevioside methanol tetrasolvate

Y. Wu, D. L. Rodenburg, M. A. Ibrahim, J. D. McChesney and M. A. Avery

Abstract: Stevioside is a naturally occurring diterpenoid glycoside in Stevia rebaudiana Bertoni. The title compound, C₃₈H₆₀O₁₈·4CH₃OH, crystallized as its methanol tetrasolvate. Stevioside consists of an aglycone steviol (a tetracyclic diterpene in which the four-fused-ring system consists of three six-membered rings and one five-membered ring) and a sugar part (three glucose units). A weak intramolecular O-HO hydrogen bond occurs. In the crystal, the methanol molecules participate in a two-dimensional hydrogen-bonded network parallel to b axis with the sugars and together they form a hydrophilic tunnel which encloses the lipophilic part of the molecule.

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