Received 16 April 2013
There are two independent and conformationally dissimilar molecules (A and B) in the asymmetric unit of the title compound, C11H6F3N3O3S; the dihedral angles between the benzene and thiazole rings are 33.8 (2)° in A and 59.7 (2)° in B. The similarity of the C-N bond lengths in the amide group [1.379 (5) and 1.358 (5) Å for A, and 1.365 (5) and 1.363 (5) Å for B] indicates the presence of conjugation between the two rings. In the crystal, molecules are linked by N-HN hydrogen bonds, forming chains extending along ; weak N-HOamide interactions are also present in the structure.
For the antiparasitic activity of nitazoxanide, see: Fox & Saravolatz (2005) and for the antibacterial activity of thiazolides, see: Gargala et al. (2010); Stachulski et al. (2011). For the synthesis and antibacterial activity of the title compound, see: Ballard et al. (2011).
Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: SHELXTL (Sheldrick, 2008); software used to prepare material for publication: SHELXTL.
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: ZS2257 ).
This study was supported by the earmarked fund for China Agriculture Research System (cars-38) and the program funded by the Basic Scientific Research Funds in Central Agricultural Scientific Research Institutions (1610322013005).
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