Acta Crystallographica Section E

Structure Reports Online

Volume 69, Part 7 (July 2013)

organic compounds

Acta Cryst. (2013). E69, o1064-o1065    [ doi:10.1107/S160053681301430X ]

3-(2,5-Di­methyl­phen­yl)-8-meth­oxy-2-oxo-1-aza­spiro­[4.5]dec-3-en-4-yl 3-(2-bromo-4-fluoro­phen­yl)acrylate

B.-R. Xu, X.-R. He, J.-L. Cheng and J.-H. Zhao

Abstract: In the title compound, C27H27BrFNO4, which is an inhibitor of acetyl-CoA carboxyl­ase, the cyclo­hexane ring displays a chair comformation with the spiro-C and meth­oxy-bearing C atoms deviating by 0.681 (7) and -0.655 (1) Å, resppectively, from the mean plane formed by the other four C atoms of the spiro-C6 ring. The mean planes of the cyclo­hexane and 2-bromo-4-fluoro­phenyl rings are nearly perpendicular to that of the pyrrolidine ring, making dihedral angles 89.75 (6) and 87.60 (9)°, respectively. In the crystal, mol­ecules are linked via pairs of N-H...O hydrogen bonds, forming inversion dimers.

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