Received 4 September 2013
aResearch Development Centre, Orchid Chemicals and Pharmaceuticals Ltd, Sozhinganallur, Chennai 600 119, India,bDepartment of Chemistry, Presidency College (Autonomous), Chennai 600 005, India, and cCentre of Advanced Study in Crystallography and Biophysics, University of Madras, Guindy Campus, Chennai 600 025, India
Correspondence e-mail: email@example.com
In the title compound, C24H27N5O2S·0.5H2O, the piperidine ring adopts a distorted boat conformation. The phenyl rings subtend dihedral angles of 69.7 (1) and 88.7 (1)° with the best plane through the piperidine moiety. In the crystal, symmetry-related molecules are linked through a network of C-HO and C-HN interactions, the former connecting them into zigzag chains along the c-axis direction and the latter forming an R22(4)motif. The dimer formation (C-HN) and the repetition of symmetry-related molecules (C-HO) along the b-axis direction stabilize the packing mode. The water molecule is located on a twofold rotation axis.
For the biological activity of piperidine derivatives, see: Aridoss et al. (2009). For puckering parameters, see: Cremer & Pople (1975). For asymmetry parameters, see: Nardelli (1983). For hydrogen-bond motifs, see: Bernstein et al. (1995).
Data collection: APEX2 (Bruker, 2008); cell refinement: SAINT (Bruker, 2008); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008); molecular graphics: ORTEP-3 for Windows (Farrugia, 2012); software used to prepare material for publication: SHELXL97 and PLATON (Spek, 2009).
Supplementary data and figures for this paper are available from the IUCr electronic archives (Reference: BT6930 ).
SG wishes to thank Orchid Chemicals and Pharmaceuticals Limited (www.orchidpharma.com), Chennai, India, for consent to perform the research. PS thanks the UGC, New Delhi, for financial support in the form of a Research Fellowship in Science for Meritorious Students.
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