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Figure 3
(a) A single protomer of apo BpGCDH (green; PDB entry 3eom ) overlaid with the human ternary complex (gray; PDB entry 1sir ; Fu et al., 2004BB12) containing FAD (black) and the substrate mimic NBC (white). Regions of structural difference between the two protomers (bacterial, magenta; human, yellow and cyan) are largely contained within terminal loop regions. (b) The interface between two protomers of bacterial (green/orange) and human (dark gray/white) GCDH. The human ternary complex reveals an α-helical contact region between protomers (yellow) which is a less ordered loop in BpGCDH (magenta). Density modeled on the opposite protomer in the human complex (cyan) is too disordered to model in the bacterial apo crystal data set.

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
Volume 67| Part 9| August 2011| Pages 1060-1069
doi:10.1107/S1744309111014436
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