Exploring the cross-reactivity of S25-2: complex with a 5,6-dehydro-Kdo disaccharide

Figure 1
(a) Ligand used for cocrystallization with S25-2: Kdo-(2 [rightwards arrow]

4)-5,6-dehydro-Kdo. (b) Structure of chlamydial LPS composed of Kdo-(2 [rightwards arrow]

8)-Kdo-(2

4)-Kdo-(2

6)-GlcN4P-(1 [rightwards arrow]

6)-GlcN1P. The Kdo-(2 [rightwards arrow]

4)-Kdo that previously cocrystallized with S25-2 (PDB entry 3t77 ; Nguyen et al., 2003

) is highlighted in red. (c) 2F_o - F_c electron-density map contoured to 1 [sigma]

around Kdo-(2 [rightwards arrow]

4)-5,6-dehydro-Kdo cocrystallized with S25-2.