Figure 4
PaIMPDH (green) superimposed onto the structure of CpIMPDH (PDB entry 3khj ; cyan) with the substrate IMP and the inhibitor C64 bound. Two residues involved in the selectivity of C64 towards the parasite enzyme IMPDH are shown and are also present in PaIMPDH. Residues marked with a prime are from the adjacent subunit that forms the catalytic tetramer.  [article HTML]