Implications of the factor H/FHL-1 binding site. (a, b) Surface representations of dimers from PDB entries 1w33
, respectively, highlighting residues Lys136, Lys141, Lys143, Glu144 and Glu47 which have been shown to be involved in factor H/FHL-1 binding (Kraiczy et al., 2009). Differences in the dimensions of the cleft between the subunits are also shown. (c) Typical dimensions of a single SCR domain. This figure was generated using PyMOL (Schrödinger LLC).