Figure 3
Structure of the Keap1 Kelch domain in complex with the Nrf2-derived peptide cycloGD77EETGE82. (a) shows the initial Fo - Fc density at a contour level of 5.0[sigma]. In (b) the polar contacts involved in binding the cyclic peptide are shown. (c) depicts a superpositioning of the cyclic peptide used in this study (grey) and the linear peptide from PDB entry 2flu (yellow).  [article HTML]

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