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Figure 4
Comparison of fragment-binding modes to known NMT ligands. (a) Fragment 2 (C atoms in slate) overlaid with a pyrazole sulfonamide ligand (C atoms in grey) bound to LmNMT (PDB entry 2wsa ). (b) Fragment 4 (C atoms in gold) overlaid with a pyridinylindole ligand (C atoms in grey) bound to LmNMT (PDB entry 4cgn ). (c) Side-chain movement of Tyr217 in the complexes with fragment 4 (C atoms in gold) and fragment 2 (C atoms in slate).

Journal logoSTRUCTURAL BIOLOGY
COMMUNICATIONS
ISSN: 2053-230X
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