forthcoming articles

The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section F: Structural Biology Communications.

See also Forthcoming articles in all IUCr journals.

Accepted 16 June 2018

Crystal structure of the effector-binding domain of Synechococcus elongatus CmpR in complex with ribulose-1,5-bis­phosphate

We report the structure of CmpR effector-binding domain (CmpR-EBD) in complex with the co-activator ribulose-1–5-bis­phosphate (RuBP) and revealed a novel ligand-binding pattern in the LTTR family.

Accepted 10 June 2018

Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae

Structure–function studies on N-acetylmannosamine-6-phosphate 2-epimerases from F. nucleatum and V. cholerae reveal conserved features among this class of epimerases.

Accepted 8 June 2018

A novel bacterial class V dye-decolourizing peroxidase from the extremophile Deinococcus radiodurans: cloning, expression optimization, purification, crystallization, initial characterization and X-ray diffraction analysis

The gene encoding a novel bacterial class V dye-decolourizing peroxidase (DyP) from the extremely radiation-resistant and desiccation-resistant bacterium D. radiodurans was cloned and optimum conditions for high-yield expression were identified. The optimized crystals diffracted to 2.2 Å resolution and the initial characterization and crystallographic analysis is promising with respect to providing highly desired insights into this largely unknown family of DyPs.

Accepted 31 May 2018

Crystal structure of Escherichia coli purine nucleoside phosphorylase complexed with a­cyclovir

The three-dimensional structure of E. coli purine nucleoside phosphorylase (PNP) complexed with acyclovir has been solved and a comparison with other complexes of PNP with guanosine derivatives has been carried out.

Accepted 31 May 2018

Cinder: keeping crystallographers app-y

A mobile application has been developed to facilitate the human annotation of crystallization images.

Accepted 29 May 2018

Crystallization and X-ray analysis of all of the players in the autoregulation of the ataRT toxin–antitoxin system

The crystallization and structural analysis of the various players in the ataRT toxin–antitoxin module from enteropathogenic Escherichia coli are reported: the toxin AtaT, the intrinsically disordered antitoxin AtaR and its complex with a 22 bp fragment of the operator DNA.

Accepted 23 May 2018

Structural polymorphism of the Escherichia coli poly-α-L-glutamate synthetase RimK

Two different conformations, closed and open forms, of the E. coli poly-α-L-glutamate synthetase protein RimK were determined in complex with the ATP analogue AMP-PNP by X-ray crystallography at 2.05 Å resolution. The structure of the open form of RimK is unique and differs substantially from the structures of its homologues.

Accepted 3 May 2018

Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum

The CAZY family GH124 endoglucanase from R. thermocellum (the organism previously known as Clostridium thermocellum) contains an unusual metal-ion site featuring a covalently modified `2-oxohistidine' residue. Atomic resolution (∼1 Å) three-dimensional analyses, in conjunction with ITC and mass spectrometry, show this metal site can accommodate a diverse array of transition metals, all of which confer a stabilizing effect on the enzyme.

Accepted 28 April 2018

Spin ballet for sweet encounters: saturation-transfer difference NMR and X-ray crystallography complement each other in the elucidation of protein–glycan interactions

Proton-based saturation-transfer difference NMR (STD-NMR) is a technique that has proven to be particularly useful in the elucidation of protein–glycan interactions. This article explains the method for non-NMR spectroscopists and uses a number of crystal structures of viral capsid proteins in complex with respective glycan receptors to compare findings by crystallography and STD-NMR side by side, highlighting the complementary nature of the approaches.

Accepted 27 April 2018

Conformations of the type-1 lacto-N-biose I unit in protein complex structures

Lacto-N-biose I units in the PDB were investigated. Instances and conformational features of the disaccharide in proteins and enzymes in the PDB from various organisms are reviewed.

Accepted 5 April 2018

Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2′-site binding inhibitor

A novel binding mode of a small-molecule inhibitor of human leukocyte elastase is revealed by its co-crystal structure with the enzyme. In the structure, a comparatively large part of the N-glycan chains attached to the enzyme are visible.

Accepted 23 March 2018

A perspective on structural and mechanistic aspects of protein O-fu­cosylation


Accepted 7 March 2018

Making glycoproteins a little bit sweeter with PDB_REDO

The results and challenges of carbohydrate handling in the current PDB_REDO databank are discussed.


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