forthcoming articles

The following articles are a selection of those recently accepted for publication in Acta Crystallographica Section F: Structural Biology Communications.

See also Forthcoming articles in all IUCr journals.

Accepted 6 December 2018

Iterative screen optimization maximizes macromolecular crystallization efficiency

An automated, high-throughput crystallographic screening method is presented and successfully used to crystallize a panel of six diverse proteins. Iterative Screening Optimization is highly customizable and easy to implement for efficient and thorough navigation of chemical space.

Accepted 4 December 2018

AtNPR4 from Arabidopsis thaliana: expression, purification, crystallization and crystallographic analysis

NPR4 has been shown to be a key regulator of the salicylic acid-mediated signal perception and transduction pathways. This project aims to obtain structural details of NPR4, thus elucidating the molecular mechanism of salicylic acid perception and its signalling role in the systemic acquired resistance pathway.

Accepted 29 November 2018

The redefined DNA-binding domain of human xeroderma pigmentosum complementation group A: production, crystallization and structure solution

The redefined DNA-binding domain (residues 98–239) of human xeroderma pigmentosum complementation group A, a scaffold protein that plays significant roles in DNA-damage verification and recruiting downstream endonucleases to facilitate the repair of DNA lesions in nucleotide-excision repair, was produced and crystallized and its structure was solved.

Accepted 20 November 2018

The structure and activity of the gluta­thione reductase from Streptococcus pneumoniae

The three-dimensional crystal structure of the glutathione reductase from S. pneumoniae is reported at 2.56 Å resolution.

Accepted 12 November 2018

The X-ray crystal structure of human endothelin 1, a polypeptide hormone regulator of blood pressure

The structure of endothelin in the unbound state has been determined using X-ray diffraction data that were collected in 1992. The crystals exhibit higher symmetry than is in fact present, and they are significantly twinned. There is a dimer containing a pseudo-twofold axis in the asymmetric unit.

Accepted 26 October 2018

Survey of the analysis of continuous conformational variability of biological macromolecules by electron microscopy

In this paper, the existing image-processing approaches in electron microscopy to analyze continuous conformational changes of biological macromolecules are reviewed.

Accepted 26 October 2018

Visualization of biological macromolecules at near-atomic resolution: cryo-electron microscopy comes of age

Transformational advances in transmission electron microscopy at cryogenic temperature (cryo-EM) is enabling atomic-level insight into the three-dimensional structure and therefore the function of biological macromolecules in solution. Contemporary cryo-EM promises to resolve problems in structural biology that were intractable just a few years ago.

Accepted 3 October 2018

On cross-correlations, averages and noise in electron microscopy

The influence of noise on cross-correlations is revisited. Equations are provided describing the influence of noise on the cross-correlations between single images and averaged images and on those between averaged images.

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