Journal of Applied Crystallography

Volume 40, Part 3 (June 2007)

research papers

J. Appl. Cryst. (2007). 40, 471-475 [ doi:10.1107/S0021889807007704 ]

Synthesis, crystal structure and biological activity of 2-[2-(quinolin-2-yl)vinyl]-8-hydroxyquinoline and 2-[2-(quinolin-4-yl)vinyl]-8-hydroxyquinoline

H.-P. Zeng, T.-T. Wang, D.-F. Xu, Y.-P. Cai and D.-F. Chen

Abstract: Two new isomeric 8-hydroxyquinoline derivatives with quinoline groups have been synthesized by Perkin condensation. Their structures were characterized by EI-MS, ¹H NMR spectroscopy, elemental analysis and FT-IR spectroscopy; crystal structures were determined by X-ray crystallography. 2-[2-(Quinolin-2-yl)vinyl]-8-hydroxyquinoline crystallizes in the tetragonal space group I4₁/a and 2-[2-(quinolin-4-yl)vinyl]-8-hydroxyquinoline crystallizes in the monoclinic space group P2₁/n. Hydrogen bonds and intermolecular interactions are observed in the compounds and stabilize their structures. The biological activities were investigated by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and flow cytometry analysis, and the results revealed that the two compounds had effects on the proliferation of rat mesenchymal stem cells.

Keywords: 8-hydroxyquinoline derivatives; stem-cell proliferation.


	Structure factor file (CIF format) (175.7 kbytes) [ doi:10.1107/S0021889807007704/kk50093asup3.hkl ] Contains datablock 3a

	Structure factor file (CIF format) (169.7 kbytes) [ doi:10.1107/S0021889807007704/kk50093bsup4.hkl ] Contains datablock 3b

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