Structural basis for light control of cell development revealed by crystal structures of a myxobacterial phytochrome

Woitowich, N.C.; Halavaty, A.S.; Waltz, P.; Kupitz, C.; Valera, J.; Tracy, G.; Gallagher, K.D.; Claesson, E.; Nakane, T.; Pandey, S.; Nelson, G.; Tanaka, R.; Nango, E.; Mizohata, E.; Owada, S.; Tono, K.; Joti, Y.; Nugent, A.C.; Patel, H.; Mapara, A.; Hopkins, J.; Duong, P.; Bizhga, D.; Kovaleva, S.E.; St. Peter, R.; Hernandez, C.N.; Ozarowski, W.B.; Roy-Chowdhuri, S.; Yang, J.-H.; Edlund, P.; Takala, H.; Ihalainen, J.; Brayshaw, J.; Norwood, T.; Poudyal, I.; Fromme, P.; Spence, J.C.H.; Moffat, K.; Westenhoff, S.; Schmidt, M.; Stojkovic, E.A.

doi:10.1107/S2052252518010631

Figure 6
Structural changes in SaBphP1 near the BV chromophore. Important residues are marked. Important salt and hydrogen bonds are shown by dashed lines. (a) Effect of adding the PHY domain. Blue atomic structure, CBD-wt; yellow atomic structure, PCM-wt. The electron density (simulated annealing OMIT mF_o − DF_c, dark blue, contour level: 2σ) is shown for the chromophore and the Thr289 (red). The red arrow indicates the overall trend of the changes. (b) Effect of the T289H mutation. Blue atomic structure: PCM-wt, yellow atomic structure: PCM-T289H. The electron density (simulated annealing mF_o − DF_c, light blue, contour level: 2σ) is shown for the chromophore and the His289 (red).

IUCrJ

Volume 5| Part 5| September 2018| Pages 619-634

ISSN: 2052-2525

https://doi.org/10.1107/S2052252518010631

BIOLOGY | MEDICINE

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