Journal of Synchrotron Radiation

Volume 20, Part 2 (March 2013)

research papers

J. Synchrotron Rad. (2013). 20, 226-233    [ doi:10.1107/S0909049513001647 ]

Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells

E. J. Sheridan, C. J. D. Austin, J. B. Aitken, S. Vogt, K. A. Jolliffe, H. H. Harris and L. M. Rendina

Abstract: The first example of synchrotron X-ray fluorescence imaging of cultured mammalian cells in cyclic peptide research is reported. The study reports the first quantitative analysis of the incorporation of a bromine-labelled cyclic RGD peptide and its effects on the biodistribution of endogenous elements (for example, K and Cl) within individual tumor cells.

Keywords: XRF; microprobe; RGD peptide; tumor cells.

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[ doi:10.1107/S0909049513001647/hf5218sup1.pdf ]
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