Journal of Synchrotron Radiation

Volume 20, Part 5 (September 2013)

research papers

J. Synchrotron Rad. (2013). 20, 721-728    [ doi:10.1107/S0909049513020074 ]

Determination of nanostructure of liposomes containing two model drugs by X-ray scattering from a synchrotron source

A. Nasedkin, J. Davidsson and M. Kumpugdee-Vollrath

Abstract: Small-angle X-ray scattering has been employed to study how the introduction of paracetamol and acetylsalicylic acid into a liposome bilayer system affects the system's nanostructure. An X-ray scattering model, developed for multilamellar liposome systems [Pabst et al. (2000), Phys. Rev. E, 62, 4000-4009], has been used to fit the experimental data and to extract information on how structural parameters, such as the number and thickness of the bilayers of the liposomes, thickness of the water layer in between the bilayers, size and volume of the head and tail groups, are affected by the drugs and their concentration. Even though the experimental data reveal a complicated picture of the drug-bilayer interaction, they clearly show a correlation between nanostructure, drug and concentration in some aspects. The localization of the drugs in the bilayers is discussed.

Keywords: SAXS; WAXS; acetylsalicylic acid; paracetamol; drug-loaded liposomes.

pdfdisplay filedownload file

Portable Document Format (PDF) file
[ doi:10.1107/S0909049513020074/co5031sup1.pdf ]
Supplementary material


To open or display or play some files, you may need to set your browser up to use the appropriate software. See the full list of file types for an explanation of the different file types and their related mime types and, where available links to sites from where the appropriate software may be obtained.

The download button will force most browsers to prompt for a file name to store the data on your hard disk.

Where possible, images are represented by thumbnails.

 bibliographic record in  format

  Find reference:   Volume   Page   
  Search:     From   to      Advanced search

Copyright © International Union of Crystallography
IUCr Webmaster