Middle segment of the CPD in patient 3. ED as viewed from the base (a, b, c) and side (d, e, f). The ED particles were located on the inner surface, within a pore, and on the outer surface. (g, h) ED displayed without the CPD, allowing the total ED burden to be measured. (c, f, h) Density profiles of ED displayed as in Fig. 5. Scale bars = 1 mm.