research papers
and behaviour of dimethyl sulfate
aISIS Facility, CCLRC – Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire OX11 0QX, England, and bSchool of Chemistry, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, Scotland
*Correspondence e-mail: r.m.ibberson@rl.ac.uk
The crystal structures of phase I and phase II of dimethyl sulfate, (CH3O)2SO2, have been determined using complementary high-resolution neutron powder and single-crystal X-ray diffraction techniques. Below its melting point of 241 K dimethyl sulfate crystallizes in an orthorhombic structure (I) in the Fdd2. On cooling below ∼175 K the crystal transforms to a monoclinic structure (II) in the I2/a. The molecule is located on a twofold axis (Z′ = 1/2) in both structures. The is of first order with strong hysteresis. The results in changes to both the intra- and the intermolecular coordination environment.
Keywords: neutron powder diffraction; single-crystal X-ray diffraction; low-temperature crystallography; phase transitions; dimethyl sulfate.
1. Introduction
Dimethyl sulfate (DMSO4) is a strong methylating agent used widely and in high volumes in industrial organic synthesis. In addition, under certain circumstances it has application as a sulfonating agent, catalyst, and solvent. Its end applications include surfactants, pesticides, water treatment chemicals, dyes and pharmaceuticals. DMSO4 is also of fundamental chemical interest in terms of understanding and predicting the general family of compounds containing sulfur-to-oxygen linkages. However, despite the importance of DMSO4, there is no information available other than a report of the structure of a 1:1 host–guest complex between DMSO4 and 18-crown-6 (Weber, 1983). Limited spectroscopic and theoretical structural studies have been reported, and these include a recent IR spectroscopy and theoretical study (Borba et al., 2005), electron diffraction and dipolometry studies (Brunvoll et al., 1981), and IR/Raman spectroscopy (Christe & Curtis, 1972). The dearth of structural information may be explained in large part by the highly toxic nature of the compound. DMSO4 is a lachrymator and likely human carcinogen that is readily absorbed through the skin.
We report here the crystal structures of two low-temperature phases of DMSO4, which, to the best of our knowledge, have not been reported previously. The handling considerations, low melting point and of DMSO4 represent particular technical difficulties for both powder and single-crystal diffraction techniques. However, the complementary use of both techniques has enabled a full and detailed structural study to be completed.
2. Experimental
Dimethyl sulfate, (CH3O)2SO2, is a clear colourless liquid with a melting point of 241 K and a boiling point of 461 K. Samples of normal (99+%) and perdeuterodimethyl sulfate (DMSO4-d6), (CD3O)2SO2, (99+%) were obtained from Sigma–Aldrich for the single-crystal X-ray and neutron powder diffraction studies, respectively. The sample is a well known carcinogen and should be handled with care.
2.1. Neutron powder diffraction measurements
Liquid DMSO4-d6 (5 g) was sealed in an 11 mm-diameter vanadium sample can. The can contained glass wool to promote the growth of fine crystallites on freezing. The sample was loaded in a vanadium-tailed `orange' cryostat at 100 K and rapidly cooled to 5 K. Time-of-flight neutron powder diffraction data were collected initially on the OSIRIS spectrometer (Telling & Andersen, 2005) at the ISIS pulsed neutron source in order to characterize the low-temperature phase behaviour. Data were recorded at 5 K at backscattering, 〈2θ〉 = 160°, over a time-of-flight range of between 11.7 and 193.2 ms, corresponding to a d-spacing range of between 0.5 and 11 Å. Under these experimental settings the instrumental resolution, Δd/d, is approximately constant and equal to 2 × 10−3. The sample was then heated in approximately 10 K steps up to 230 K before cooling back to 5 K in 7 K steps. At each temperature during this sequence diffraction profiles were recorded for a period of 10 µAh (ca 12 min) over a restricted time-of-flight range of 29.4–69.4 ms (1.7–4.1 Å).
High-resolution powder data were also recorded using HRPD (Ibberson et al., 1992) at ISIS at 225 K (130 µAh, ca 3.5 h) and 5 K (68 µAh, ca 2 h). Data were recorded at backscattering, 〈2θ〉 = 168°, over a time-of-flight range of between 30 and 130 ms, corresponding to a d-spacing range of between 0.6 and 2.6 Å. Under these experimental settings the instrumental resolution, Δd/d, is approximately constant and equal to 8 × 10−4. A standard data reduction procedure was followed for both instruments; the data were normalized to the incident-beam monitor profile and corrected for detector efficiency effects using a previously recorded vanadium spectrum.
A section of the thermogram recorded on OSIRIS on cooling is shown in Fig. 1 and clearly identifies the around 175 K. The diffraction patterns recorded using OSIRIS at 5 and 230 K were indexed on the basis of the positions of the first 20 peaks using DICVOL91 (Boultif & Louër, 1991). At 5 K the cell is monoclinic: a = 8.674 (2), b = 5.812 (1), c = 9.936 (2) Å, β = 100.42 (2)°. At 230 K the cell is orthorhombic: a = 12.061 (2), b = 15.907 (3), c = 5.797 (1) Å. Both structures were solved by simulated annealing implemented by TOPAS-Academic (Coelho, 2000) using a molecular template based on earlier electron diffraction data (Brunvoll et al., 1981). The phase II structure at 5 K was solved initially in P21/n. The structure was then refined against the HRPD 5 K data, and the symmetry was increased to I2/a following analysis with the program MISSYM, a component of the PLATON suite (Spek, 2003). Details of the are given in Table 11 and the final profile fit is shown in Fig. 2. The phase I structure was solved in Fdd2; however, attempts to refine the structure were unsatisfactory. All powder data sets in this phase showed a strong texture, despite the presence of glass wool in the sample can, which could not be modelled adequately. This uncertainty resulted in unrealistic molecular bond lengths and angles following attempts to refine the atomic coordinates and nonphysical values for the isotropic displacement parameters. Under normal circumstances a high-quality powder sample would be produced simply by hand grinding; however, owing to handling issues associated with such a highly toxic material, single-crystal methods were chosen as described below.
The variable-temperature data sets recorded on OSIRIS were subsequently analysed using models based on the final refined structures for each phase. In these refinements the molecular geometry was fixed and the only structural parameters refined were the lattice constants and two atomic displacement parameters: one for D atoms and one for the remaining S, C and O atoms. In the region of the transition, the coexisting phases were both refined where possible. Data recorded on warming suffered a number of interruptions due to problems with the neutron source. These (three) interruptions are the most likely cause of deviations from the expected smooth variation of the lattice parameters with temperature (Fig. 3). In comparatively rapid measurements such as these, the sample is never in true thermal equilibrium with the surroundings. This does not pose a significant problem if a constant heating and measurement time `ramp' is maintained. Interrupting this ramp sequence, however, allows the sample to attain true thermal equilibrium and is the cause of the apparent discontinuities in the By contrast, no such major interruptions were experienced while recording data on cooling, as can be seen in the figure.
2.2. X-ray single-crystal diffraction measurements
Liquid DMSO4 was loaded into a capillary of 0.75 mm diameter. Data were collected on a Bruker SMART APEX CCD diffractometer equipped with an Oxford Cryosystems low-temperature device and an OHCD laser-assisted crystal growth device (Boese & Nussbaumer, 1994). The crystal was grown at 220 K using the Boese laser-assisted zone method. The diffraction pattern was indexed using GEMINI (Sparks, 1999) and integrated with SAINT (Siemens, 1995). 63 reflections were used for indexing, and of these 36 could be indexed using one orientation matrix and 23 of the remaining 27 reflections were indexed to a second matrix. The sample is thus composed mainly of two crystals, but the is such that reflection overlap between domains was not expected to be a significant problem. Accordingly all subsequent manipulations were carried out using a single orientation matrix and the data collection strategy was optimized using COSMO (Bruker, 2003) to collect a hemisphere of data in the range 2θ < 54°. The structure was solved by DIRDIF (Beurskens et al., 1996) in Fdd2. Details of the using CRYSTALS (Betteridge et al., 2003) are given in Table 1.
The sample was then cooled to 180 K and a second data set collected. The crystal was shown to have undergone a transition to a monoclinic I-centred phase. 893 reflections were used for indexing and all but 43 could be indexed on one of five orientation matrices. It is interesting to note that the benefit of the reconstructive in the powder study of breaking up crystallites has now become problematic in the single-crystal study. The structure was again solved using (see supplementary data) and found to be in agreement with the phase II structure of the powder study.
3. Results
3.1. The phase I crystal structure
The structure of phase I DMSO4 has half a molecule in the with the central S atom located on a twofold axis. The molecules interact via four main H⋯H contacts in the range 2.53 (2)–3.09 (2) Å. (Here the C—H bonds have been normalized to 1.08 Å to enable direct comparison with the neutron-derived phase II structure described below.) The shortest contact between H42 and H43 (following the − x, −y, + z) forms zigzag chains of H⋯H—C—H⋯H interactions linking two columns of molecules projected onto the ac plane. These molecular chains are in turn cross-linked by a single short contact between H41 and O2 (following the − x, + y, + z) of 2.29 (2) Å in the [012] and [02] direction. The structure is illustrated in Fig. 4.
Within this C2 symmetry and adopts a V-shaped consistent with the most stable conformer determined by matrix-isolation FT–IR spectroscopy and theoretical methods (Borba et al., 2005). The C—O—S—O torsion angle is 68.13 (11)° compared with 74.3° from theory. The gas-phase electron diffraction studies (Brunvoll et al., 1981) also report such a V-shaped conformation, albeit with a much reduced C—O—S—O torsion angle of 47 (2)°. The methyl group conformation in the phase I structure has one C—H bond antiperiplanar relative to the S—O2 bond and is also in agreement with the spectroscopic and theoretical studies discussed above. The libration of the molecule in the structure is high but not unexpectedly so at 200 K, which is close to the melting point of 241 K. Selected intramolecular dimensions corrected for libration are given in Table 2.
the molecule exhibits
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3.2. The phase II crystal structure
The structure of phase II DMSO4 similarly has half a molecule in the with the central S atom sitting on a twofold axis. The short ca 5.8 Å axis in phase I is retained as the b axis in the phase II structure, and in this case the molecules interact via six main D⋯D contacts in the range 2.470 (2)–3.032 (2) Å. The shortest of these contacts is between D41 and D42 (following the 1 − x, + y, − z) and links the molecules into sheets in the crystallographic ac plane, as illustrated in Fig. 5. Despite these changes in the crystal packing motif the intramolecular geometry is largely retained. The C—O—S—O torsion angle is reduced by only 2–64.56°. The main change in in phase II is that the methyl groups are rotated by 20° compared with the ideal conformation observed in phase I (Table 2).
4. Discussion of the phase I and phase II structures and behaviour
The molecular dimensions and conformation in the two phases are unexceptional and in remarkable agreement (Table 2). There is also broad agreement with the molecular dimensions for the DMSO4 complex with 18-crown-6 (Weber, 1983). In the latter, no molecular symmetry is imposed by the and the equivalent S1—O2 bond lengths are 1.405 (6) and 1.416 (6) Å, and for S1—O3 1.544 (4) and 1.525 (4) Å. The methyl group conformation in the host–guest complex leads to equivalent S1—O3—C4—H41 torsion angles of 178 and −167°, which are approaching the ideal conformation and are in line with the phase I structure.
The variation in the unit-cell volume of the phase I and phase II structures is shown in Fig. 3. There is a large hysteresis associated with the transition temperature; on warming Tc ≃ 210 K and on cooling Tc ≃ 175 K. This hysteresis and the coexistence of both phases in the region of the transition are characteristic of first-order behaviour. Below the transition temperature, the cell volume, the a and c axes, and the β angle of the phase II structure all show a smooth decrease with temperature. In contrast, the b axis shows a small but significant increase with decreasing temperature.
Analysis of the Voronoi–Dirichlet polyhedron constructed only on the basis of the distribution of the molecular centroids (the `lattice' VDP) in phase I (high-T phase; Fig. 6) shows that the coordination sequence is 14–52–114. This is close to body-centred cubic topology (perfect CS = 14–50–110), and is characterized by eight centroid–centroid distances in the range 6.62–6.69 Å, and six in the range 5.20–5.80 Å. A similar analysis of phase II yields the same coordination sequence with two distances of 7.60 Å, four of 6.73 Å and eight of 5.13–5.81 Å. Following Peresypkina & Blatov (2000a,b) in neglecting the very shortest contacts and recalculating the coordination sequence yields 12–42–92. This corresponds to cubic close-packed topology and hence the more efficient packing of phase II. This packing is confirmed by a significant reduction in the molecular volume at the transition. For example, in phase I at 167 K each molecule occupies 138.57 (5) Å3 compared with 130.38 (1) Å3 in phase II, a decrease of some 6%. The reduction in molecular volume is accompanied by a related reduction in the intermolecular H⋯H close contacts as described above. This optimal structure is realized with the accompanying changes to the methyl group conformation away from the ideal theoretical prediction.
Finally, anomalous behaviour is observed in the unit-cell expansion of phase II when compared on warming and cooling. At 5 K the unit-cell volumes and lattice constants in the two cases are equivalent (Fig. 3). However, above 50 K the thermal expansivity of the cell volume for the heating sequence is markedly lower when compared with the cooling sequence. Similar behaviour is shown by the a, c and b lattice constants, whereas the b lattice constant exhibits a less negative expansion. The thermal treatment of the sample offers a likely explanation for this observation. The sample was initially quenched at 100 K and then cooled to 5 K. Data recorded on warming this sample were composed entirely of the phase II structure until the transition onset around 210 K. In contrast, the phase II sample for the cooling sequence was transformed via the phase I structure and lattice parameters for both phases could be refined down to 167 K. Very weak peaks corresponding to the phase I structure were in fact observed down to 100 K. The intergrowth of phase II and phase I structures and sluggish nature of the transition would both affect the observed thermal expansivity of phase II in the cooling sequence.
5. Conclusions
The smaller molecular volume of DMSO4 in the phase II structure as compared with the phase I structure is accompanied by a rotation of the methyl groups away from ideal C2 molecular symmetry found in the gas phase and phase I The first-order transition into phase II is thus driven by relieving the intermolecular steric interactions at the expense of retaining a near ideal intramolecular conformation.
Supporting information
10.1107/S0108768106001893/ws5036sup1.cif
contains datablocks me2so4_180k, me2so4_220k, me2so4_5k. DOI:Rietveld powder data: contains datablock me2s04_5k. DOI: 10.1107/S0108768106001893/ws5036sup2.rtv
Structure factors: contains datablock ME2SO4_180K. DOI: 10.1107/S0108768106001893/ws5036me2so4_180ksup3.hkl
Structure factors: contains datablock me2so4_220K. DOI: 10.1107/S0108768106001893/ws5036me2so4_220ksup4.hkl
Acknowledgements
This work has been supported by the CCLRC with the provision of neutron beam time.
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