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Figure 2
Illustration of the use of multiscale imaging combining different instrumentation ranging from whole animal imaging (rendered mouse is 8.7 cm from nose to start of tail) with in vivo µCT (or clinical CT for humans) over laboratory µCT to map individual bones/bone pieces (rendered mouse femur is 16 mm long) to higher resolution in-house X-ray microscopy that reveals inter­ior structure (reconstructed cross section of mouse mid-femur is 1.9 mm from top to bottom), including osteo­cyte lacunae typically 10–15 µm long, to synchrotron imaging that can be conducted in high throughput sub-µm resolution mode to investigate large volumes and a large number of specimens or in nanotomography mode to reveal fine details, such as the canaliculi of the lacuno-canalicular network (length of the rendered mouse osteo­cyte lacuna is 15 µm). Adapted from data reported in Wittig et al. (2022BB49).

ISSN: 2052-5206
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