Figure 9
Stereogram of the superposition of the active-site residues of human pepsin–inhibitor complex (blue) with those of a metalloproteinase, thermolysin, in complex with a phosphonamidate inhibitor (red) (Holden et al., 1987; PDB code 4tmn). The superposition was performed by aligning the Cα atoms of the P1 and P1′ residues and the atom that corresponds to the carbonyl O atom of a substrate. |