Figure 4
(a) Schematic diagram of one pair of overlapping Fabs bound to neighbouring VP6 trimers. Each VP6 trimer has three epitopes which do not overlap. The first step in both fitting methods is to mask off the density corresponding to the VP6 (b). In the extraction method one Fab is masked off (c) and in the overlap zone of the Fabs a proportion of the density is replaced in the map to recreate one Fab. |