Figure 1
Effect of model completeness on evolutionary search efficiency. Results are shown for polyalanine and all-atom search models that were incrementally truncated at the carboxy-terminal end by roughly 10% of the total residues (11–12 residues) at a time. The evolutionary search used a population size of 300 evolving over 50 generations and data between 15 and 4 Å resolution. The diffraction data used in this test was from PDB entry 6rhn
, histidine triad nuclear binding protein (Brenner et al., 1997). The search models were derived from the refined coordinates of the same protein determined in a different crystal form (PDB entry 4rhn
, 115 residues). |