Figure 2
(a) RIBBONS (Carson, 1991 ) representation of the intact BoNT/B molecule. The bound doxorubicin molecule is shown as a ball-and-stick model, with the van der Waals surface as a dotted surface. (b) GRASP (Nicholls et al., 1991 ) representation of the surface curvature of the C-fragment of BoNT/B with doxorubicin shown as a stick model. The orientation of the molecule is similar to that of (a). |