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Figure 8
Like the SAD case, there is also an ambiguity in single isomorphous replacement (SIR). (a) With the measured amplitudes of the native protein (FP) and heavy-atom derivative (FPH) amplitudes and the calculated heavy-atom contribution (FH), there are in general two possible solutions for the protein phase φP symmetrically placed around the heavy-atom phase φH. (b) The error treatment leads to the probability distribution of the protein phase.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 58| Part 11| October 2002| Pages 1958-1967
doi:10.1107/S0907444902016645
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