Figure 1
(a) Schematic diagram of the automatic setup for crystal detection by birefringence. Crystalline material is identified by rotating both the polarizing filters simultaneously, making birefringent material light up and extinguish. (b) Crystalline material shows up as light patches in an otherwise dark background using the setup described in (a). Here, 70 different wells, each containing 10 nl of mother liquor, are simultaneously evaluated for crystal growth. The evaluation time is less than 1 min. Wherever crystalline material is present the polarized light is repolarized, so it is no longer extinguished by the analysing polarization filter. The setup easily detects crystals smaller than 10 µm in size. |