view article
Figure 1
The catalytic pathways of PTR1, DHFR and DHPR. PTR1 and DHFR both take the fully oxidized pteridine via the 7,8-dihydro intermediate to the 5,6,7,8-tetrahydro product. DHPR, on the other hand, uses quinonoid dihydrobiopterin to produce tetrahydrobiopterin. PTR1 and DHFR prefer NADPH as the cofactor, whereas DHPR prefers NADH. The molecular weights of PTR1, DHFR and DHPR are 29.2, 18.1 and 25.4 kDa, respectively. The active form of PTR1 is a tetramer, that of DHFR a monomer and that of DHPR a dimer.

Journal logoBIOLOGICAL
CRYSTALLOGRAPHY
ISSN: 1399-0047
Volume 59| Part 9| August 2003| Pages 1539-1544
doi:10.1107/S0907444903013131
Follow Acta Cryst. D
Sign up for e-alerts
E-alerts
Follow Acta Cryst. on Twitter
Twitter
Follow us on facebook
Facebook
Sign up for RSS feeds
RSS