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Figure 2
Porcupine plot of the principal mode of conformational variability calculated from a CONCOORD ensemble. (a) The principal mode of motion for MDM2/apo is dominated by a closing of the p53 cleft, indicated by the convergence of the cones on the two lips of the cleft. (b) Orthogonal view of the principal mode of MDM2/p53. This view is dominated by a pair of antiparallel vortices at each end of the molecule, indicative of a two-lobed flexing.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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