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Figure 7
Reconfiguration of MDM2/p53 when the peptide is removed and the structure is simulated by MD. A significant closure of the peptide-binding cleft is observed in the apo structure (blue) compared with the peptide-bound form (cyan). |
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Figure 7
Reconfiguration of MDM2/p53 when the peptide is removed and the structure is simulated by MD. A significant closure of the peptide-binding cleft is observed in the apo structure (blue) compared with the peptide-bound form (cyan). |