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Figure 1
(a) Error-scaled difference distance matrix comparing the Cα-atom positions of 1fmk and 2src ; (b) schematic view of Src kinase, with conformationally invariant regions indicated by different colours. The substrate analogue is shown with C atoms in orange. Selected side chains are depicted with C atoms in the colour of the respective domain. Yellow: SH3 domain, Tyr136, Asp117. Green: SH2 domain, Pro250, Tyr527. Light blue: N-terminal lobe of the kinase domain, Lys255. Dark blue: C-terminal lobe of the kinase domain, Arg318. Flexible parts are shown in grey and red; grey indicates that the respective residues are involved in a crystal contact in at least one of the two crystal forms.

Journal logoBIOLOGICAL
ISSN: 1399-0047
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