The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods

Kemp, L.E.; Alphey, M.S.; Bond, C.S.; Ferguson, M.A.J.; Hecht, S.; Bacher, A.; Eisenreich, W.; Rohdich, F.; Hunter, W.N.

doi:10.1107/S0907444904025971

Acta Crystallographica Section D
Acta Crystallographica
Section D BIOLOGICAL CRYSTALLOGRAPHY

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Figure 7
Overlay of two structures in the region of the hydrophobic cleft: the original 1.8 Å resolution orthorhombic form and the P2₁ crystal form. GPP is depicted as a semi-transparent surface coloured red for O and slate blue for C atoms. The protein residues are shown in stick mode, coloured grey for C, blue for N and red for O atoms. Selected amino acids are labelled.

BIOLOGICAL
CRYSTALLOGRAPHY

ISSN: 1399-0047

Volume 61| Part 1| December 2005| Pages 45-52

doi:10.1107/S0907444904025971

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